Author

J. N. Johnston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1

Frequent Co-Authors

A. N. Smith· 2 shared B. C. Knollmann· 2 shared D. J. Blackwell· 2 shared J. A. Schwarz· 2 shared R. L. Cornea· 2 shared A. Gochman· 1 shared A. V. Zima· 1 shared B. Svensson· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. N. Smith

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

ent-Verticilide B1 inhibits type 2 ryanodine receptor channels and is antiarrhythmic in Casq2-/- mice

A. Gochman, T. Q. Do, K. Kim, J. A. Schwarz, M. P. Thorpe, D. J. Blackwell, A. N. Smith, W. S. Akers, R. L. Cornea, D. L. Laver, J. N. Johnston, B. C. Knollmann

This paper identifies ent-verticilide B1 as an antiarrhythmic compound that inhibits RyR2 channels and reduces arrhythmias in Casq2-/- mice.

bioRxiv · Jul 3, 2023 · PreprintPharmacology & Toxicology

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET

J. Seflova, J. A. Schwarz, A. N. Smith, B. Svensson, D. J. Blackwell, T. A. Phillips, R. Nikolaienko, E. Bovo, R. T. Rebbeck, A. V. Zima, D. D. Thomas, F. Van Petegem, B. C. Knollmann, J. N. Johnston, S. L. Robia, R. L. Cornea

The paper maps the binding site of ent-verticilide on RyR2 using FRET and computational methods, identifying two potential loci within the RyR2 structure.

bioRxiv · Jun 22, 2023 · PreprintBiophysics