Author

A. N. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

B. C. Knollmann· 2 shared D. J. Blackwell· 2 shared J. A. Schwarz· 2 shared J. N. Johnston· 2 shared R. L. Cornea· 2 shared A. Castillo· 1 shared A. Gochman· 1 shared A. Holt-Jones· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersPharmacology & Toxicology

B. C. Knollmann

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Intrauterine Growth-Restricted Pregnant Rats, from Hypertensive Placental Ischemic Dams Display Preeclamptic-like Symptoms: A New Rodent Model of Preeclampsia

J. Smith, M. Powell, W. Cromartie, S. Smith, K. Jones, A. Castillo, J. Shaw, J. Editone, A. Howard-Cunningham, R. Tatum, A. N. Smith, B. Fisher, G. W. Booz, M. W. CUNNINGHAM

This study establishes a new rodent model of preeclampsia by inducing intrauterine growth restriction in pregnant rats, showing elevated blood pressure and oxidative stress.

bioRxiv · Feb 7, 2024 · PreprintPhysiology

ent-Verticilide B1 inhibits type 2 ryanodine receptor channels and is antiarrhythmic in Casq2-/- mice

A. Gochman, T. Q. Do, K. Kim, J. A. Schwarz, M. P. Thorpe, D. J. Blackwell, A. N. Smith, W. S. Akers, R. L. Cornea, D. L. Laver, J. N. Johnston, B. C. Knollmann

This paper identifies ent-verticilide B1 as an antiarrhythmic compound that inhibits RyR2 channels and reduces arrhythmias in Casq2-/- mice.

bioRxiv · Jul 3, 2023 · PreprintPharmacology & Toxicology

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET

J. Seflova, J. A. Schwarz, A. N. Smith, B. Svensson, D. J. Blackwell, T. A. Phillips, R. Nikolaienko, E. Bovo, R. T. Rebbeck, A. V. Zima, D. D. Thomas, F. Van Petegem, B. C. Knollmann, J. N. Johnston, S. L. Robia, R. L. Cornea

The paper maps the binding site of ent-verticilide on RyR2 using FRET and computational methods, identifying two potential loci within the RyR2 structure.

bioRxiv · Jun 22, 2023 · PreprintBiophysics

Adaptive thermogenesis in mice requires adipocyte light-sensing via Opsin 3

G. Nayak, S. Vemaraju, K. X. Zhang, Y. Odaka, E. D. Buhr, A. Holt-Jones, A. N. Smith, B. A. Upton, J. J. Zhan, N. Diaz, K. Murakami, S. D'Souza, M.-T. Nguyen, S. A. Gordon, G. Wu, , R. A. Lang

This study shows that blue light sensed by OPN3 in adipocytes regulates thermogenesis and lipolysis in mice.

bioRxiv · Aug 1, 2019 · PreprintPhysiology