Author

J. A. Schwarz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Ecology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:ecology & biodiversity· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

R. L. Cornea· 3 shared A. N. Smith· 2 shared B. C. Knollmann· 2 shared B. Svensson· 2 shared D. D. Thomas· 2 shared D. J. Blackwell· 2 shared F. Van Petegem· 2 shared J. N. Johnston· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiophysics

R. L. Cornea

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

ent-Verticilide B1 inhibits type 2 ryanodine receptor channels and is antiarrhythmic in Casq2-/- mice

A. Gochman, T. Q. Do, K. Kim, J. A. Schwarz, M. P. Thorpe, D. J. Blackwell, A. N. Smith, W. S. Akers, R. L. Cornea, D. L. Laver, J. N. Johnston, B. C. Knollmann

This paper identifies ent-verticilide B1 as an antiarrhythmic compound that inhibits RyR2 channels and reduces arrhythmias in Casq2-/- mice.

bioRxiv · Jul 3, 2023 · PreprintPharmacology & Toxicology

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET

J. Seflova, J. A. Schwarz, A. N. Smith, B. Svensson, D. J. Blackwell, T. A. Phillips, R. Nikolaienko, E. Bovo, R. T. Rebbeck, A. V. Zima, D. D. Thomas, F. Van Petegem, B. C. Knollmann, J. N. Johnston, S. L. Robia, R. L. Cornea

The paper maps the binding site of ent-verticilide on RyR2 using FRET and computational methods, identifying two potential loci within the RyR2 structure.

bioRxiv · Jun 22, 2023 · PreprintBiophysics

Cardiac RyR N-terminal region biosensors for FRET-based high-throughput screening

J. Zhang, S. M. W. K. Yuen, J. A. Schwarz, L. M. Treinen, C.-C. Tung, R. T. Rebbeck, K. Ro?man, B. Svensson, C. C. Aldrich, D. D. Thomas, F. Van Petegem, R. L. Cornea

This study develops FRET-based biosensors to screen for RyR modulators, identifying novel inhibitors and activators with therapeutic potential.

bioRxiv · Feb 7, 2021 · PreprintBiophysics

Hydraulic diversity stabilizes productivity in a large-scale subtropical tree biodiversity experiment

F. Schnabel, X. Liu, M. Kunz, K. E. Barry, F. J. Bongers, H. Bruelheide, A. Fichtner, W. Härdtle, S. Li, C.-T. Pfaff, B. Schmid, J. A. Schwarz, Z. Tang, B. Yang, J. Bauhus, , C. Wirth

The paper shows that tree species richness stabilizes forest productivity through increased species asynchrony and hydraulic trait diversity, not community-weighted means.

bioRxiv · Jan 6, 2021Ecology