Author

J. O'Prey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

K. Ryan· 2 shared S. Tait· 2 shared A. J. Chalmers· 1 shared A. Koessinger· 1 shared A. Oberst· 1 shared A. Wheeler· 1 shared C. Cloix· 1 shared C. Nixon· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

K. Ryan

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics

A. Koessinger, D. Koessinger, K. Kinch, L. Martinez-Escardo, N. Paul, Y. Elmasry, G. Malviya, C. Cloix, K. Campbell, F. Bock, J. O'Prey, K. Stevenson, C. Nixon, M. Jackson, G. Ichim, , S. Tait

This study shows that glioblastoma (GBM) is highly sensitive to BH3-mimetics due to elevated anti-apoptotic BCL-xL and MCL-1 expression, which can be therapeutically targeted.

bioRxiv · Jun 13, 2021 · PreprintCancer Biology

Activated BAX/BAK enable mitochondrial inner membrane permeabilisation and mtDNA release during cell death

J. Riley, G. Quarato, J. Lopez, J. O'Prey, M. Pearson, J. Chapman, H. Sesaki, L. Carlin, J. Passos, A. Wheeler, A. Oberst, K. Ryan, S. Tait

This study shows that BAX/BAK-mediated mitochondrial outer membrane pores widen after MOMP, leading to inner membrane permeabilisation and mtDNA release, which triggers inflammation via cGAS-STING.

bioRxiv · Feb 26, 2018Cell Biology