DDK inhibition disrupts replication leading to mitotic catastrophe in Ewing sarcoma
J. C. Martin, A. Gupta, T. J. Hagoel, L. Gao, M. L. Lynch, A. Woloszynska, T. Melendy, J. Kane, J. Kuechle, J. Ohm
This study shows that DDK inhibition causes replication stress and mitotic catastrophe in Ewing sarcoma cells, reducing viability and suggesting DDK as a therapeutic target.
bioRxiv · Nov 2, 2021 · PreprintCancer Biology