Author

J. Kane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Bruna· 1 shared A. C. Shockey· 1 shared A. G. Martin· 1 shared A. Giovannetti· 1 shared A. Gupta· 1 shared A. K. Klimowicz· 1 shared A. Nagano· 1 shared A. Shea· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperCancer Biology

A. Bruna

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Modelling drug responses and evolutionary dynamics using triple negative breast cancer patient-derived xenografts

A. Shea, Y. Eyal-Lubling, D. Guerrero-Romero, R. Manzano Garcia, W. Greenwood, M. O'Reilly, D. Georgopoulou, M. Callari, G. Lerda, S. Wix, A. Giovannetti, R. Masina, E. Esmaeilishirazifard, A. G. Martin, A. Nagano, , A. Bruna

This paper uses TNBC patient-derived xenografts to model drug responses and evolutionary dynamics, revealing a novel mechanism of olaparib response and synergistic effects with salinomycin.

bioRxiv · Jan 10, 2023 · PreprintCancer Biology

DDK inhibition disrupts replication leading to mitotic catastrophe in Ewing sarcoma

J. C. Martin, A. Gupta, T. J. Hagoel, L. Gao, M. L. Lynch, A. Woloszynska, T. Melendy, J. Kane, J. Kuechle, J. Ohm

This study shows that DDK inhibition causes replication stress and mitotic catastrophe in Ewing sarcoma cells, reducing viability and suggesting DDK as a therapeutic target.

bioRxiv · Nov 2, 2021 · PreprintCancer Biology

Transcriptional and translational responsiveness of the Neisseria gonorrhoeae type IV secretion system to conditions of host infections

M. M. Callaghan, A. K. Klimowicz, A. C. Shockey, J. Kane, C. Pepperell, J. P. Dillard

The paper identifies conditions that increase Neisseria gonorrhoeae type IV secretion system expression through transcriptional and translational mechanisms, and shows upregulation of these genes during urethral infection.

bioRxiv · Feb 12, 2021Microbiology