J. C. Martin

Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative Colitis.

The paper identifies myeloid cell influx and epithelial cell perturbations in ulcerative colitis, linking them to disease severity and anti-TNF therapy non-response.

Radiation-induced persistent DNA damage response and late toxicity in cardiac tissue

This study investigates early and late cardiac toxicity in irradiated A/J mice, identifying persistent DNA damage and macrophage polarization as potential contributors to long-term cardiac complications.

Enterotoxigenic Escherichia coli heat-labile toxin drives enteropathic changes in small 1intestinal epithelia

This study shows that ETEC heat-labile toxin causes long-term intestinal damage beyond diarrhea, affecting nutrient absorption and growth in mice.

Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors

The paper identifies two CAF subsets in human lung tumors that promote T cell exclusion through distinct matrix programs and spatial organization.

DDK inhibition disrupts replication leading to mitotic catastrophe in Ewing sarcoma

This study shows that DDK inhibition causes replication stress and mitotic catastrophe in Ewing sarcoma cells, reducing viability and suggesting DDK as a therapeutic target.

IL-22BP production is heterogeneously distributed in Crohn's disease

This study investigates IL-22BP production and distribution in Crohn's disease tissues, finding higher levels in ileum and associations with eosinophils, moDCs, and smoking.

Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Transcriptional and Biochemical Function

This study identifies a JAK1 mutation causing autoinflammation and shows its unique transcriptional and functional effects through single-cell analysis and clinical treatment.

An easy and reliable whole blood freezing method for flow cytometry immuno- phenotyping and functional analyses

This paper introduces a whole blood freezing method using CryoStor(R) CS10 solution, demonstrating preserved cell viability and functional markers for flow cytometry analyses.

Oral administration of an anti-CfaE secretory IgA antibody protects against Enterotoxigenic Escherichia coli diarrheal disease in a non-human primate model

This study evaluates the efficacy of secretory IgA2 and dimeric IgA2 antibodies against ETEC in a non-human primate model, finding that oral SIgA2 significantly reduced diarrheal attack rates.

Serum Amyloid A Proteins Induce Pathogenic TH17 Cells and Promote Inflammatory Disease

This study shows serum amyloid A proteins drive pathogenic TH17 cell differentiation and promote inflammatory disease through STAT3-activating cytokines.

Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy