Author

J. Osipiuk

Argonne National Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1 Organism:virus· 1

Frequent Co-Authors

A. JoachimiakiD· 3 shared K. MichalskaiD· 2 shared A. Das· 1 shared B. T. Lanham· 1 shared Bryan C. DickinsoniD· 1 shared C. Chang· 1 shared C. TayloriD· 1 shared C. Tesar· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

A. JoachimiakORCID

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Author profile →

3 papers

Recent·Most cited

Molecular basis for dual functions in pilus assembly modulated by the lid of a pilus-specific sortase

C. Chang, H. Ton-That, J. Osipiuk, A. Joachimiak, A. Das, H. Ton-That

This study identifies the structural basis for the dual function of SrtC2 in pilus assembly by showing how its extended lid modulates polymerization and anchoring activities.

Journal of Biological Chemistry · Jun 1, 2024Peer-reviewedMicrobiology

Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin

P. M. Wydorski, J. Osipiuk, B. T. Lanham, C. Tesar, M. Endres, E. Engle, R. Jedrzejczak, V. Mullapudi, K. Michalska, K. Fidelis, D. Fushman, A. Joachimiak, L. A. Joachimiak

This study identifies how SARS-CoV-2 PLpro selectively binds human ISG15 and K48-linked di-ubiquitin through dual domain recognition, revealing potential drug targets.

bioRxiv · Sep 15, 2021 · PreprintBiophysics

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

J. Osipiuk, Saara‐Anne Azizi, Steve Dvorkin, Michael J Endres, Robert P. Jedrzejczak, Krysten A. Jones, Soowon Kang, Rahul S. Kathayat, Youngchang Kim, Vladislav G. Lisnyak, S. Maki, Vlad I. Nicolaescu, C. Taylor, Christine Tesar, Yu‐An Zhang, , A. Joachimiak

This paper reports structural and biochemical studies of SARS-CoV-2 papain-like protease and its complexes with inhibitors, showing their ability to inhibit enzyme activity and viral replication.

Nature Communications · Feb 2, 2021Peer-reviewedMolecular Biology