Author

Vlad I. Nicolaescu

University of ChicagoORCID 0000-0002-6347-0232Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Assay:multiome· 1 Assay:protein structure· 1 Organism:virus· 1

Frequent Co-Authors

A. JoachimiakiD· 2 shared Glenn C. RandalliD· 2 shared K. MichalskaiD· 2 shared Robert P. JedrzejczakiD· 2 shared Soowon KangiD· 2 shared Youngchang KimiD· 2 shared Aaron Esser-Khan· 1 shared Ani SolankiiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

A. JoachimiakORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Polymer-lipid hybrid nanoparticle enhances mRNA delivery and T cell-mediated immunity

Xiaolei Cai, Min Chen, Guoshuai Cao, Nicholas W. Asby, Derek Elli, Haley Gula, Vlad I. Nicolaescu, Duy-Thuc Nguyen, Xiaodan Huang, Tanushree Dangi, Ani Solanki, Sara Woessner, Wenbo Zhang, Erting Tang, Lisa R. Volpatti, , Jun Huang

This study develops a polymer-lipid hybrid nanoparticle (PLNP) to enhance mRNA delivery and T cell immunity, showing improved antigen-specific T cell responses and protection against viral variants and cancer.

bioRxiv · Jan 24, 2026 · PreprintImmunology

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2

Youngchang Kim, Jacek Wower, N. Maltseva, Changsoo Chang, Robert P. Jedrzejczak, Mateusz Wilamowski, Soowon Kang, Vlad I. Nicolaescu, Glenn C. Randall, K. Michalska, A. Joachimiak

The paper shows that Tipiracil inhibits SARS-CoV-2 Nsp15 by binding to its uridine site, supporting its potential as a drug scaffold for antiviral development.

Communications Biology · Feb 9, 2021Peer-reviewedMolecular Biology

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

J. Osipiuk, Saara‐Anne Azizi, Steve Dvorkin, Michael J Endres, Robert P. Jedrzejczak, Krysten A. Jones, Soowon Kang, Rahul S. Kathayat, Youngchang Kim, Vladislav G. Lisnyak, S. Maki, Vlad I. Nicolaescu, C. Taylor, Christine Tesar, Yu‐An Zhang, , A. Joachimiak

This paper reports structural and biochemical studies of SARS-CoV-2 papain-like protease and its complexes with inhibitors, showing their ability to inhibit enzyme activity and viral replication.

Nature Communications · Feb 2, 2021Peer-reviewedMolecular Biology