Author

C. M. West

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

E. Gas-Pascual· 3 shared H. van der Wel· 3 shared M. Mandalasi· 3 shared C. G. Baptista· 2 shared H. W. Kim· 2 shared I. Blader· 2 shared A. Dittmar· 1 shared A. Eletsky· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

E. Gas-Pascual

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Toxoplasma gondii F-Box Protein L2 Silences Feline-Restricted Genes Necessary for Sexual Commitment

C. G. Baptista, S. Hosking, E. Gas-Pascual, L. Ciampossine, S. Abel, M.-A. Hakimi, V. Jeffers, K. G. Le Roch, C. M. West, I. Blader

This paper identifies TgFBXL2, an F-box protein in Toxoplasma gondii, which represses feline-restricted genes required for sexual commitment by modulating SCF-E3 ubiquitin ligase activity.

bioRxiv · Dec 18, 2023 · PreprintMicrobiology

The Toxoplasma Oxygen Sensing Protein, TgPhyA, Is Required for Resistance to Interferon-gamma Mediated Nutritional Immunity

C. Cordonnier, M. Mandalasi, J. P. Gigley, E. Wohlfert, C. M. West, I. Blader

This study shows that TgPHYa, an oxygen-sensing protein in Toxoplasma, is essential for parasite virulence and survival in immune cells by enabling tryptophan scavenging during IFN-gamma-induced nutritional immunity.

bioRxiv · May 16, 2023 · PreprintMicrobiology

The nucleocytosolic O-fucosyltransferase Spindly affects protein expression and virulence in Toxoplasma gondii

G. Bandini, C. Agop-Nersesian, H. van der Wel, M. Mandalasi, H. Kim, C. M. West, J. Samuelson

This paper identifies TgSPY as the O-fucosyltransferase in Toxoplasma gondii, showing it modifies proteins but is not essential for growth, yet affects protein levels and virulence in mice.

bioRxiv · Aug 30, 2020Microbiology

A glycogenin homolog controls Toxoplasma gondii growth via glycosylation of an E3 ubiquitin ligase

M. Mandalasi, H. W. Kim, D. Thieker, M. O. Sheikh, E. Gas-Pascual, K. Rahman, P. Zhao, N. G. Daniel, H. van der Wel, T. H. Ichikawa, J. N. Glushka, L. Wells, R. J. Woods, Z. A. Wood, C. M. West

This study identifies Gat1, a glycogenin homolog, as essential for adding the terminal sugar to Skp1 in Toxoplasma gondii, which is critical for parasite growth.

bioRxiv · Feb 2, 2020 · PreprintMicrobiology

Skp1 Dimerization Conceals its F-box Protein Binding Site

H. W. Kim, A. Eletsky, K. J. Gonzalez, H. van der Wel, E.-M. Strauch, J. H. Prestegard, C. M. West

This paper investigates how Skp1 dimerization hides its F-box protein binding site, showing that a mutation disrupts dimerization and allows Skp1 to bind F-box proteins.

bioRxiv · Jan 26, 2020Biochemistry

Independence of HIF1a and androgen signaling pathways in prostate cancer

M. G. Tran, B. A. Bibby, L. Yang, F. Lo, A. Warren, D. Shukla, M. Osborne, J. Hadfield, T. Carroll, R. Stark, H. Scott, A. Ramos-Montoya, C. Massie, P. Maxwell, C. M. West, , D. Neal

The paper investigates the relationship between HIF1a and androgen signaling pathways in prostate cancer, finding they operate independently and identify shared genes associated with poor prognosis.

bioRxiv · Nov 26, 2019Cancer Biology

Toxoplasma F-Box Protein 1 is Required for Daughter Cell Scaffold Function During Parasite Replication

C. G. Baptista, A. Lis, B. Deng, E. Gas-Pascual, A. Dittmar, W. Sigurdson, C. M. West, I. J. Blader

This paper identifies TgFBXO1 as an F-box protein essential for daughter cell scaffold function in Toxoplasma gondii, demonstrating its role in parasite replication.

bioRxiv · Jun 14, 2019Microbiology