Author

M. Mandalasi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

C. M. West· 3 shared H. van der Wel· 2 shared C. Agop-Nersesian· 1 shared C. Cordonnier· 1 shared D. Thieker· 1 shared E. Gas-Pascual· 1 shared E. Wohlfert· 1 shared G. Bandini· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

C. M. West

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Author profile →

3 papers

Recent·Most cited

The Toxoplasma Oxygen Sensing Protein, TgPhyA, Is Required for Resistance to Interferon-gamma Mediated Nutritional Immunity

C. Cordonnier, M. Mandalasi, J. P. Gigley, E. Wohlfert, C. M. West, I. Blader

This study shows that TgPHYa, an oxygen-sensing protein in Toxoplasma, is essential for parasite virulence and survival in immune cells by enabling tryptophan scavenging during IFN-gamma-induced nutritional immunity.

bioRxiv · May 16, 2023 · PreprintMicrobiology

The nucleocytosolic O-fucosyltransferase Spindly affects protein expression and virulence in Toxoplasma gondii

G. Bandini, C. Agop-Nersesian, H. van der Wel, M. Mandalasi, H. Kim, C. M. West, J. Samuelson

This paper identifies TgSPY as the O-fucosyltransferase in Toxoplasma gondii, showing it modifies proteins but is not essential for growth, yet affects protein levels and virulence in mice.

bioRxiv · Aug 30, 2020Microbiology

A glycogenin homolog controls Toxoplasma gondii growth via glycosylation of an E3 ubiquitin ligase

M. Mandalasi, H. W. Kim, D. Thieker, M. O. Sheikh, E. Gas-Pascual, K. Rahman, P. Zhao, N. G. Daniel, H. van der Wel, T. H. Ichikawa, J. N. Glushka, L. Wells, R. J. Woods, Z. A. Wood, C. M. West

This study identifies Gat1, a glycogenin homolog, as essential for adding the terminal sugar to Skp1 in Toxoplasma gondii, which is critical for parasite growth.

bioRxiv · Feb 2, 2020 · PreprintMicrobiology