Author

H. Francis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

C. G. Bailey· 2 shared A. A. Cross-Najafi· 1 shared A. Franke· 1 shared A. Isidan· 1 shared A. Viswanathan· 1 shared B. Ekser· 1 shared B. Ngo· 1 shared B. Schnabl· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

C. G. Bailey

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Development of Scaffold-free 3D Cholangiocyte Organoids to Study the Progression of Primary Sclerosing Cholangitis

W. Zhang, K. Kyritsi, A. Isidan, Y. Park, P. Li, A. A. Cross-Najafi, K. Lopez, L. Kennedy, K. Sato, S. Glaser, H. Francis, G. Alpini, B. Ekser

The paper develops scaffold-free 3D cholangiocyte organoids to study primary sclerosing cholangitis progression and confirms PSC-specific phenotypes.

bioRxiv · Oct 24, 2022Bioengineering

Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in PSC.

M. Awoniyi, J. Wang, B. Ngo, V. Meadows, J. Tam, A. Viswanathan, Y. Lai, S. Montgomery, M. Farmer, M. Kummen, L. B. Thingholm, C. Schramm, C. Bang, A. Franke, B. Schnabl, , R. B. Sartor

This study identifies protective and aggressive bacterial subsets and metabolites in PSC patients and mice, showing their impact on hepatobiliary inflammation and fibrosis.

bioRxiv · Oct 31, 2021 · PreprintMicrobiology

Unique Protein Interaction Networks Define The Chromatin Remodeling Module of The NuRD Complex

M. Sharifi Tabar, C. Giardina, Y. Feng, H. Francis, H. Moghaddassani, J. K. K. Low, J. P. Mackay, C. G. Bailey, J. E. J. Rasko

The paper identifies paralogue-specific protein interactions of the MGCC module in the NuRD complex, revealing mechanisms for functional specificity and integration into other complexes.

bioRxiv · Jan 27, 2021Biochemistry

Somatic mutations in CTCF zinc fingers produce cellular phenotypes explained by structure-function relationships

J. E. Rasko, C. G. Bailey, S. Gupta, C. Metierre, P. Amarasekera, P. O'Young, W. Kyaw, T. Laletin, H. Francis, C. Semaan, K. Singh, C. Mullighan, O. Wolkenhauer, U. Schmitz

This study identifies somatic CTCF mutations in cancer and shows how their structure-function relationships affect cellular phenotypes and tumour suppressor function.

bioRxiv · Jan 8, 2021Cancer Biology