Author

J. K. Low

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:Bayesian inference· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Norman· 2 shared J. Mackay· 2 shared J. P. Mackay· 2 shared K. Patel· 2 shared M. J. Jackman· 2 shared M. J. Landsberg· 2 shared R. J. Payne· 2 shared T. Passioura· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

A. Norman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome

J. K. Low, K. Patel, P. Solomon, A. Norman, P. Pachl, N. Jones, R. J. Payne, T. Passioura, H. Suga, L. J. Walport, J. Mackay

The paper uses mRNA display to identify high-affinity bromodomain-binding motifs not present in the human proteome, revealing novel binding modes and suggesting evolutionary pressure against strong binders.

bioRxiv · May 17, 2023Biochemistry

Molecular architecture of nucleosome remodeling and deacetylase sub-complexes by integrative structure determination

S. Arvindekar, M. J. Jackman, J. K. Low, M. J. Landsberg, J. P. Mackay, S. Viswanath

This study determines the molecular architecture of three NuRD sub-complexes using integrative structural methods, revealing new subunit interfaces and MBD3 localization.

bioRxiv · Nov 25, 2021Biophysics

Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein using mRNA Display

A. Norman, C. Franck, M. Christie, P. Hawkins, K. Patel, A. Ashhurst, A. Aggarwal, J. K. Low, R. Siddiquee, C. Ashley, M. Steain, J. A. Triccas, S. G. Turville, J. Mackay, T. Passioura, R. J. Payne

The paper identifies cyclic peptide ligands to the SARS-CoV-2 spike protein RBD using mRNA display, finding six high-affinity molecules with nanomolar dissociation constants.

ACS Central Science · Jun 23, 2021Peer-reviewedBiochemistry

The Nucleosome Remodeling and Deacetylase complex has an asymmetric, dynamic, and modular architecture

J. K. Low, A. P. Silva, M. Sharifi Tabar, M. Torrado, S. R. Webb, B. L. Parker, M. Sana, C. Smits, J. W. Schmidberger, L. Brillault, M. J. Jackman, D. C. Williams, G. A. Blobel, S. B. Hake, N. E. Shepherd, , J. P. Mackay

This study reveals the asymmetric and dynamic architecture of the NuRD complex using integrated biochemical and structural methods.

bioRxiv · Feb 17, 2020Biochemistry