Author

L.-Y. Chiu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1

Frequent Co-Authors

A. E. Hargrove· 2 shared B. S. Tolbert· 2 shared Z. Cai· 2 shared A. Donlic· 1 shared A. Jalali· 1 shared A. L. Sugarman· 1 shared A. M. Lentzsch· 1 shared A. Sugarman· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

A. E. Hargrove

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

R-BIND 2.0: An Updated Database of Bioactive RNA-Targeting Small Molecules and Associated RNA Secondary Structures

A. Donlic, E. G. Swanson, L.-Y. Chiu, S. L. Wicks, A. Umuhire Juru, Z. Cai, K. J. Kassam, C. Laudeman, B. Sanaba, A. Sugarman, E. Han, B. S. Tolbert, A. E. Hargrove

R-BIND 2.0 updates the database of RNA-targeting small molecules by refining curation, analyzing RNA structures, and introducing a search algorithm for structure-based ligand discovery.

bioRxiv · Mar 14, 2022Biochemistry

Small Molecule Targeting IRES Domain Inhibits Enterovirus 71 Replication via an Allosteric Mechanism that Stabilizes a Ternary Complex

J. Davila-Calderon, N. N. Patwardhan, L.-Y. Chiu, A. L. Sugarman, Z. Cai, S. R. Penutmutchu, M.-L. Li, G. Brewer, A. E. Hargrove, B. S. Tolbert

The paper identifies a small molecule that inhibits EV71 replication by stabilizing a ternary complex with RNA and AUF1 protein via an allosteric mechanism.

bioRxiv · Mar 10, 2020Biochemistry

Bacteria-to-human protein networks reveal origins of endogenous DNA damage

J. Xia, L.-Y. Chiu, R. B. Nehring, M. A. Bravo Nunez, Q. Mei, M. Perez, Y. Zhai, D. M. Fitzgerald, J. P. Pribis, Y. Wang, C. W. Hu, R. T. Powell, S. A. LaBonte, A. Jalali, M. L. Matadamas Guzman, , S. M. Rosenberg

The paper identifies DNA-damaging proteins in E. coli and their human homologs, showing they promote endogenous DNA damage and are overrepresented in cancer drivers.

bioRxiv · Jun 26, 2018Cancer Biology