Author

J. P. Wisniewski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Organism:rat· 1

Frequent Co-Authors

A. M. Chinnaiyan· 2 shared C. A. Lyssiotis· 2 shared C. Cheng· 2 shared L. Xiao· 2 shared R. Mannan· 2 shared T. He· 2 shared X. Cao· 2 shared Y. Qiao· 2 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. M. Chinnaiyan

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2 papers

Recent·Most cited

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

C. Cheng, J. Hu, R. Mannan, R. Bhattacharyya, N. J. Rossiter, B. Magnuson, J. P. Wisniewski, Y. Zheng, L. Xiao, C. Li, D. Awad, T. He, Y. Bao, Y. Zhang, X. Cao, , A. M. Chinnaiyan

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

bioRxiv · Mar 18, 2024Cancer Biology

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

T. He, C. Cheng, Y. Qiao, H. Cho, E. Young, R. Mannan, S. Mahapatra, S. J. Miner, Y. Zheng, N. Kim, V. Z. Zeng, J. P. Wisniewski, S. Hou, B. Jackson, X. Cao, , A. M. Chinnaiyan

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

bioRxiv · Feb 29, 2024Cancer Biology