Author

J. Paik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:mouse· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

H. Zheng· 4 shared I. Hwang· 4 shared J. Yao· 3 shared F. Li· 2 shared H. Ying· 2 shared B. Hu· 1 shared C. Wu· 1 shared D. Cao· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersCancer Biology

H. Zheng

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

F. Li, Y. Wang, I. Hwang, J.-Y. Janng, L. Zhou, Z. Deng, E. Y. Yu, Y. Cai, C. Wu, Z. Han, Y.-H. Huang, X. Huang, L. Zhang, J. Yao, N. Lue, , H. Zheng

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

bioRxiv · Feb 10, 2023 · PreprintCancer Biology

Therapy-induced transdifferentiation promotes glioma growth independent of EGFR signaling

H. Oh, I. Hwang, L. Wu, D. Cao, J. Yao, H. Ying, J. Y. Li, Y. Yao, B. Hu, Q. Wang, H. Zheng, J. Paik

This study identifies therapy-induced transdifferentiation as a mechanism of EGFR-targeted therapy resistance in gliomas, independent of EGFR signaling, and suggests combinatorial therapies targeting both EGFR and transdifferentiation pathways.

bioRxiv · Jun 2, 2020Cancer Biology

Cellular Stress Signaling Activates Type-I IFN Response Through FOXO3-regulated Lamin Posttranslational Modification

I. Hwang, Z. Dai, F. Li, T. Sanchez, J. W. Locasale, L. L. Cantley, H. Zheng, J. Paik

The paper shows that oxidative stress in NSPCs activates the IFN-I response via FOXO3-regulated lamin modifications, preserving their regenerative potential.

bioRxiv · May 3, 2020Cell Biology

CIC is a Critical Regulator of Neuronal Differentiation

I. Hwang, H. Pan, J. Yao, O. Elemento, H. Zheng, J. Paik

This study identifies CIC as a critical regulator of neuronal differentiation by repressing VGF expression through a corepressor complex, linking its dysfunction to brain tumor development.

bioRxiv · Oct 9, 2019Cell Biology