H. Ying

Nanoclustering and signaling of KRAS G12C and KRAS G12D respond to lipid acyl chain remodeling in an allele-specific manner

This study shows that KRAS G12C and G12D mutants respond differently to lipid acyl chain remodeling, affecting their nanoclustering and signaling activities.

KRAS inhibition activates an actionable CD24 do-not-eat-me signal in pancreatic cancer

This study identifies CD24 as an actionable signal activated by KRASG12C inhibition in pancreatic cancer, enhancing macrophage phagocytosis and sensitizing tumors to therapy.

Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner

This study shows that MRTX1133, a KrasG12D inhibitor, reduces early pancreatic lesions and, when combined with immunotherapy, regresses advanced PDAC by enhancing CD8+ T cell activity.

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

Microbiota mediated plasticity promotes thermal adaptation in Nematostella vectensis

This study shows that microbiota-mediated plasticity enables thermal adaptation in Nematostella vectensis, with acclimated microbiota transferable to offspring.

Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition

This study shows that combining glucose metabolism inhibition with MEK inhibition enhances apoptosis in pancreatic cancer cells by inducing ER stress.

Hyaluronic Acid Fuels Pancreatic Cancer Growth

This study shows hyaluronic acid fuels pancreatic cancer metabolism by bypassing GFAT1 via the GlcNAc salvage pathway, enabling proliferation in nutrient-starved conditions.

Morphological stasis masks ecologically divergent coral species on tropical reefs

This study identifies ecologically divergent cryptic coral lineages within a morphologically uniform species, revealing that morphological stasis can mask ecological divergence.

The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2

This study shows that the pancreatic tumor microenvironment compensates for loss of GOT2 by providing pyruvate, maintaining redox homeostasis and tumor growth in vivo.

Therapy-induced transdifferentiation promotes glioma growth independent of EGFR signaling

This study identifies therapy-induced transdifferentiation as a mechanism of EGFR-targeted therapy resistance in gliomas, independent of EGFR signaling, and suggests combinatorial therapies targeting both EGFR and transdifferentiation pathways.

YAP1 Oncogene is a Context-specific Driver for Pancreatic Ductal Adenocarcinoma

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

Novel pipeline of high-frequency neoantigens heathy donor-based validation in breast cancer

The paper develops a computational pipeline to identify high-frequency neoantigens in breast cancer and validates their immunogenicity using healthy donor blood samples.

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF signaling in KMT2D Mutant Melanoma

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.

Simulation of Karyotype Evolution and Biodiversity in Asexual and Sexual Reproduction

This study simulates how sexual and asexual reproduction affect genome-level diversity and biodiversity, finding that asexual populations show higher genome-level diversity while sexual populations show lower diversity.