Sphingomyelins in mosquito saliva modify the host lipidome to enhance transmission of flaviviruses by promoting viral protein levels
H. Medkour, L. Pruvost, X. Gong, V. Vaissayre, P. Boutinaud, J. Revel, A. Hitakarun, W. Sornjai, J. Zoladek, D. R. Smith, S. Nisole, E. Nolte-t Hoen, J. bertrand-Michel, D. Misse, G. Marti, J. Pompon
This study identifies sphingomyelins in mosquito salivary extracellular vesicles that enhance flavivirus transmission by altering the host lipidome and increasing viral protein levels.
bioRxiv · Jun 14, 2024 · PreprintPathology