Author

J. R. Brewer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

E. Kaffe· 2 shared R. A. Flavell· 2 shared Y. Kluger· 2 shared A. G. York· 1 shared A. Han· 1 shared A. Iwasaki· 1 shared A.-B. Marcher· 1 shared B. Israelow· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersImmunology

E. Kaffe

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit inflammation

A. G. York, M. H. Skadow, R. G. Qu, J. Oh, W. K. Mowel, J. R. Brewer, E. Kaffe, K. J. Williams, Y. Kluger, J. M. Crawford, S. M. Smale, S. J. Bensinger, R. A. Flavell

This study shows IL-10 limits inflammation by restricting sphingolipid metabolism through fatty acid desaturation, with metabolic correction reducing inflammation in IL-10-deficient macrophages.

bioRxiv · May 7, 2023 · PreprintImmunology

Nanostructure of the desmosomal plaque

I. Iachina, H. Gam-Hadberg, J. R. Brewer

This study uses 3D-STED microscopy to reveal the 3D nanostructure of desmosomes in mouse and human epidermis, showing ring-like structures and changes in desmoplakin distribution across skin layers.

bioRxiv · Apr 18, 2022 · PreprintCell Biology

Inflammasome activation in infected macrophages drives COVID-19 pathology

E. Sefik, R. Qu, C. Junqueira, E. Kaffe, H. Mirza, J. Zhao, J. R. Brewer, A. Han, H. R. Steach, B. Israelow, H. N. Blackburn, S. Velazquez, Y. G. Chen, S. Halene, A. Iwasaki, , R. A. Flavell

This study shows SARS-CoV-2 infection of human macrophages drives COVID-19 pathology through inflammasome activation, leading to inflammation and pyroptosis, but also enabling viral release.

bioRxiv · Sep 27, 2021Immunology

The Epidermal Barrier is Indispensable for Systemic Energy Homeostasis

D. Neess, V. Kruse, A.-B. Marcher, M. R. Waede, J. Vistisen, P. M. Moeller, R. Petersen, J. R. Brewer, T. Ma, G. Colleluori, I. Severi, S. Cinti, Z. Gerhart-Hines, S. Mandrup, N. J. Faergeman

This study shows that a compromised epidermal barrier increases energy expenditure, food intake, and white adipose tissue browning while preventing diet-induced obesity.

bioRxiv · Sep 1, 2020Biochemistry