Author

Y. Kluger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2

Frequent Co-Authors

R. A. Flavell· 4 shared J. Zhao· 3 shared E. Kaffe· 2 shared E. Sefik· 2 shared J. R. Brewer· 2 shared R. Qu· 2 shared S. Halene· 2 shared A. Adonyi· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersImmunology

R. A. Flavell

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

IL-10 constrains sphingolipid metabolism via fatty acid desaturation to limit inflammation

A. G. York, M. H. Skadow, R. G. Qu, J. Oh, W. K. Mowel, J. R. Brewer, E. Kaffe, K. J. Williams, Y. Kluger, J. M. Crawford, S. M. Smale, S. J. Bensinger, R. A. Flavell

This study shows IL-10 limits inflammation by restricting sphingolipid metabolism through fatty acid desaturation, with metabolic correction reducing inflammation in IL-10-deficient macrophages.

bioRxiv · May 7, 2023 · PreprintImmunology

Autologous humanized PDX modeling for immuno-oncology recapitulates the human tumor microenvironment

M. Chiorazzi, J. Martinek, B. Krasnick, Y. Zheng, K. J. Robbins, R. Qu, G. Kaufmann, Z. Skidmore, L. A. Henze, F. Brosecke, A. Adonyi, J. Zhao, L. Shan, E. Sefik, J. Mudd, , R. A. Flavell

This study develops an autologous humanized PDX model to study tumor-immune interactions and demonstrates its utility in preclinical testing by showing VEGF-A inhibition reduces tumor growth.

bioRxiv · Aug 19, 2022 · PreprintCancer Biology

Inflammasome activation in infected macrophages drives COVID-19 pathology

E. Sefik, R. Qu, C. Junqueira, E. Kaffe, H. Mirza, J. Zhao, J. R. Brewer, A. Han, H. R. Steach, B. Israelow, H. N. Blackburn, S. Velazquez, Y. G. Chen, S. Halene, A. Iwasaki, , R. A. Flavell

This study shows SARS-CoV-2 infection of human macrophages drives COVID-19 pathology through inflammasome activation, leading to inflammation and pyroptosis, but also enabling viral release.

bioRxiv · Sep 27, 2021Immunology

Alignment free identification of clones in B cell receptor repertoires

O. Lindenbaum, N. Nouri, Y. Kluger, S. Kleinstein

The paper introduces an alignment-free method to identify clones in B cell receptor repertoires, improving sensitivity without sacrificing specificity compared to junction-based distance methods.

bioRxiv · Mar 30, 2020Immunology

A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical Studies

Y. Song, A. Rongvaux, A. Taylor, T. Jiang, T. Tebaldi, K. Balasubramanian, A. Bagale, Y. K. Terzi, R. Gbyli, X. Wang, J. Zhao, N. Podoltsev, M. Xu, N. Neparidze, E. Wong, , S. Halene

This paper develops a novel MDS patient-derived xenotransplantation model in MISTRG mice that faithfully represents all MDS subtypes and enables effective drug testing.

bioRxiv · Feb 14, 2018Cancer Biology