Author

B. Israelow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:human· 4 Organism:mouse· 4 Assay:proteomics· 3 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Iwasaki· 7 shared C. B. Wilen· 4 shared E. Song· 4 shared T. Mao· 4 shared A. Casanovas-Massana· 2 shared A. Ko· 2 shared A. Ring· 2 shared B. L. Menasche· 2 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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7 shared papersImmunology

A. Iwasaki

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Inflammasome activation in infected macrophages drives COVID-19 pathology

E. Sefik, R. Qu, C. Junqueira, E. Kaffe, H. Mirza, J. Zhao, J. R. Brewer, A. Han, H. R. Steach, B. Israelow, H. N. Blackburn, S. Velazquez, Y. G. Chen, S. Halene, A. Iwasaki, , R. A. Flavell

This study shows SARS-CoV-2 infection of human macrophages drives COVID-19 pathology through inflammasome activation, leading to inflammation and pyroptosis, but also enabling viral release.

bioRxiv · Sep 27, 2021Immunology

A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice

T. Mao, B. Israelow, C. Lucas, C. B. F. Vogels, O. Fedorova, M. I. Breban, B. L. Menasche, H. Dong, M. Linehan, Yale SARS-CoV-2 Genome Surveillance Initiative, C. B. Wilen, M. L. Landry, N. D. Grubaugh, A. M. Pyle, A. Iwasaki

This study shows that SLR14, a RIG-I agonist, prevents and treats SARS-CoV-2 infection in mice, including chronic cases and variants, through IFN-I responses.

bioRxiv · Jun 16, 2021Immunology

High-affinity, neutralizing antibodies to SARS-CoV-2 can be made in the absence of T follicular helper cells

J. S. Chen, R. D. Chow, E. Song, T. Mao, B. Israelow, K. Kamath, J. Bozekowski, W. A. Haynes, R. B. Filler, B. L. Menasche, J. Wei, M. M. Alfajaro, W. Song, L. Peng, L. Carter, , S. C. Eisenbarth

The paper shows that high-affinity, neutralizing antibodies against SARS-CoV-2 can be produced without T follicular helper cells through alternative pathways.

bioRxiv · Jun 10, 2021Immunology

Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2

B. Israelow, T. Mao, J. Klein, E. Song, B. Menasche, S. B. Omer, A. Iwasaki

The paper investigates the roles of humoral and cellular immunity in SARS-CoV-2 clearance and protection against a variant, finding antibodies mediate protection in both vaccinated and naturally infected mice.

bioRxiv · May 19, 2021Immunology

Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

E. Song, C. M. Bartley, R. D. Chow, T. Ngo, R. Jiang, C. R. Zamecnik, R. Dandekar, R. Loudermilk, Y. Dai, F. Liu, I. Hawes, B. D. Alvarenga, T. Huynh, L. McAlpine, N.-T. Rahman, , S. F. Farhadian

The paper identifies CNS-specific immune alterations in COVID-19 patients with neurological symptoms, suggesting neuroinvasion and anti-neural autoimmunity as potential causes.

bioRxiv · Sep 11, 2020Immunology

Neuroinvasion of SARS-CoV-2 in human and mouse brain

E. Song, C. Zhang, B. Israelow, A. Lu-Culligan, A. Sprado, S. Skriabine, P. Lu, O.-E. Weizman, F. Liu, Y. Dai, K. Szigeti-Buck, Y. Yasumoto, G. Wang, C. Castaldi, J. Heltke, , A. Iwasaki

This study investigates SARS-CoV-2 neuroinvasion in human and mouse brains using organoids, in vivo models, and autopsies, finding evidence of neuronal infection and its consequences.

bioRxiv · Jun 25, 2020Microbiology

Detection of SARS-CoV-2 RNA by multiplex RT-qPCR

E. Kudo, B. Israelow, C. Vogels, P. Lu, A. L. Wyllie, M. Tokuyama, A. Venkataraman, D. E. Brackney, I. Ott, M. Petrone, R. Earnest, S. Lapidus, C. Muenker, A. Moore, A. Casanovas-Massana, , A. Iwasaki

This paper develops a multiplex RT-qPCR assay for SARS-CoV-2 detection that uses existing primer/probe sets and reduces reagents, costs, time, and labor compared to singleplex assays.

bioRxiv · Jun 16, 2020Microbiology