Author

S. Houten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Biochemistry· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Assay:metabolomics· 2 Assay:protein structure· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

C. Argmann· 3 shared C. Yu· 3 shared P. Ranea-Robles· 3 shared T. Dodatko· 3 shared D. Bhattacharya· 2 shared H. Chen· 2 shared J. Leandro· 2 shared M. Puchowicz· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersPhysiology

C. Argmann

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Characterization, structure and inhibition of the human succinyl-CoA:glutarate-CoA transferase, a genetic modifier of glutaric aciduria type 1

S. Khamrui, T. Dodatko, R. Wu, J. Leandro, A. Sabovic, S. Violante, J. R. Cross, E. Marsan, K. Kumar, R. DeVita, M. B. Lazarus, S. Houten

The paper characterizes the human SUGCT enzyme, determines its structure, and identifies inhibitors that may lead to new treatments for glutaric aciduria type 1.

bioRxiv · Feb 7, 2024Biochemistry

Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1

J. Leandro, S. Khamrui, C. Suebsuwong, P.-J. Chen, C. Secor, T. Dodatko, C. Yu, R. Sanchez, R. DeVita, S. Houten, M. Lazarus

The paper characterizes the human LOR domain of AASS, presents its crystal structure, and identifies it as a potential drug target for glutaric aciduria type 1.

bioRxiv · May 20, 2022Biochemistry

The peroxisomal transporter ABCD3 plays a major role in dicarboxylic fatty acid metabolism

P. Ranea-Robles, H. Chen, B. Stauffer, C. Yu, D. Bhattacharya, S. L. Friedman, M. Puchowicz, S. Houten

This study investigates the role of ABCD3 in DCA metabolism using an Abcd3 KO mouse model and shows its impact on lipid homeostasis and metabolic compartmentalization.

bioRxiv · Jul 26, 2021Physiology

PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

N. M. Wickramasinghe, D. Sachs, B. Shewale, D. M. Gonzalez, P. Dhanan-Krishnan, D. Torre, E. LaMarca, S. Raimo, R. Dariolli, M. Serasinghe, J. Mayourian, R. Sebra, K. G. Beaumont, R. Iyengar, D. L. French, , N. C. Dubois

This study shows that activating PPARD signaling enhances metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

bioRxiv · Jul 12, 2021 · PreprintCell Biology

Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis

P. Ranea-Robles, S. Violante, C. Argmann, T. Dodatko, D. Bhattacharya, H. Chen, C. Yu, S. L. Friedman, M. Puchowicz, S. Houten

This study investigates the role of EHHADH in DCA β-oxidation and its impact on hepatic cholesterol homeostasis in mice, finding that EHHADH deficiency leads to 3-hydroxydicarboxylic aciduria and altered cholesterol synthesis.

bioRxiv · Mar 2, 2021Physiology

Dietary restriction in the long-chain acyl-CoA dehydrogenase knockout mouse

E. Diekman, M. van Weeghel, M. Suarez-Farinas, C. Argmann, P. Ranea-Robles, R. Wanders, G. Visser, I. van der Made, E. Creemers, S. Houten

This study examines the effects of dietary restriction on plasma metabolites and cardiac function in LCAD KO mice, finding minimal impact on metabolites and no cardiac remodeling.

bioRxiv · Dec 3, 2020Physiology

Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2 related disease

M. Suarez-Farinas, M. Tokuyama, G. Wei, R. Huang, A. Livanos, D. Jha, A. Levescot, H. Irizar, R. Kosoy, S. Cording, W. Wang, H. Irizar, R. Ungaro, A. Di Narzo, G. Martinez-Delgado, , S. Mehandru

The paper examines how intestinal inflammation affects ACE2 and TMPRSS2 expression and identifies shared molecular networks between COVID-19 and IBD.

bioRxiv · May 21, 2020Immunology