Author

S. Khamrui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

J. Leandro· 3 shared T. Dodatko· 3 shared C. Secor· 2 shared C. Suebsuwong· 2 shared C. Yu· 2 shared M. B. Lazarus· 2 shared R. DeVita· 2 shared R. Sanchez· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersBiochemistry

J. Leandro

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3 papers

Recent·Most cited

Characterization, structure and inhibition of the human succinyl-CoA:glutarate-CoA transferase, a genetic modifier of glutaric aciduria type 1

S. Khamrui, T. Dodatko, R. Wu, J. Leandro, A. Sabovic, S. Violante, J. R. Cross, E. Marsan, K. Kumar, R. DeVita, M. B. Lazarus, S. Houten

The paper characterizes the human SUGCT enzyme, determines its structure, and identifies inhibitors that may lead to new treatments for glutaric aciduria type 1.

bioRxiv · Feb 7, 2024Biochemistry

Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1

J. Leandro, S. Khamrui, C. Suebsuwong, P.-J. Chen, C. Secor, T. Dodatko, C. Yu, R. Sanchez, R. DeVita, S. Houten, M. Lazarus

The paper characterizes the human LOR domain of AASS, presents its crystal structure, and identifies it as a potential drug target for glutaric aciduria type 1.

bioRxiv · May 20, 2022Biochemistry

Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex

J. Leandro, S. Khamrui, H. Wang, C. Suebsuwong, N. S. Nemeria, K. Huynh, M. Moustakim, C. Secor, M. Wang, T. Dodatko, B. Stauffer, C. G. Wilson, C. Yu, M. R. Arkin, F. Jordan, , S. M. Houten

This study identifies DHTKD1 inhibitors and reports its crystal structure with thiamin diphosphate, revealing how mutations affect its function and stability.

bioRxiv · Jan 20, 2020Biochemistry