J. R. Fletcher

Staphylococcus aureus overcomes anaerobe-derived short-chain fatty acid stress via FadX and the CodY regulon

This paper shows that S. aureus uses FadX and the CodY regulon to resist short-chain fatty acid stress from anaerobic bacteria in CRS.

The Stickland fermentation precursor trans-4-hydroxyproline differentially impacts the metabolism of Clostridioides difficile and commensal Clostridia

This study investigates how trans-4-hydroxyproline affects the metabolism of C. difficile and commensal Clostridia, revealing differential gene expression and microbiota changes in mice.

Dual oxic-anoxic co-culture enables direct study of host-anaerobe interactions at the airway epithelial interface

The paper introduces a dual oxic-anoxic co-culture system to study host-anaerobe interactions in airway epithelial cells and shows its utility in revealing mucus degradation and transcriptional responses to anaerobe infection.

Age-related reductions in the number of serial sarcomeres contribute to shorter fascicle lengths but not elevated passive tension

This study examines age-related changes in muscle architecture, finding shorter fascicle lengths and reduced serial sarcomere numbers in older rats, but no elevation in passive tension.

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota

This study shows C. difficile uses toxin-induced inflammation to alter host nutrient availability and outcompete Bacteroides by utilizing collagen-derived amino acids.