Author

J. R. Murphy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:metabolomics· 1

Frequent Co-Authors

S. Parveen· 3 shared W. R. Bishai· 3 shared S. Lun· 2 shared A. Kumar· 1 shared B. Koleske· 1 shared B. S. Slusher· 1 shared D. Sharma· 1 shared J. D. Powell· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

S. Parveen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis

S. Parveen, J. Shen, S. Lun, L. Zhao, B. Koleske, R. D. Leone, R. Rais, J. D. Powell, J. R. Murphy, B. S. Slusher, W. R. Bishai

This study shows that JHU083, a glutamine metabolism inhibitor, reduces Mtb growth and modulates host immunity in tuberculosis, with effects dependent on host factors.

bioRxiv · Feb 23, 2023 · PreprintMicrobiology

Effective host-directed therapy for tuberculosis by targeted depletion of myeloid-derived suppressor cells using a diphtheria toxin-based fusion protein

S. Parveen, S. Lun, M. E. Urbanowski, M. Cardin, J. R. Murphy, W. R. Bishai

This study shows that depleting myeloid-derived suppressor cells (MDSCs) using a diphtheria toxin-based fusion protein reduces Mycobacterium tuberculosis burden in mice.

bioRxiv · Dec 10, 2020Microbiology

IL-4 receptor targeting as an effective immunotherapy against triple-negative breast cancer

S. Parveen, S. Siddharth, L. S. Cheung, A. Kumar, J. R. Murphy, D. Sharma, W. R. Bishai

This paper demonstrates that DABIL-4, a fusion toxin targeting IL-4R, effectively reduces TNBC tumor growth and metastasis by depleting both tumor cells and immunosuppressive cells in the tumor microenvironment.

bioRxiv · Aug 5, 2020 · PreprintImmunology