Author

D. C. Turner

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Physiology· 5 Cell Biology· 1

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Assay:DNA methylation· 5 Organism:human· 5 Approach:statistical model· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. P. Sharples· 6 shared R. A. Seaborne· 5 shared P. P. Gorski· 4 shared D. J. Owens· 3 shared A. K. Larin· 2 shared B. Drust· 2 shared C. E. Stewart· 2 shared D. C. Hughes· 2 shared

Activity by Year

2019-2023 · peak 3/yr

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10 top collaborators · 44 mutual co-author links

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6 shared papersPhysiology

A. P. Sharples

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6 papers

Recent·Most cited

Human skeletal muscle methylome after low carbohydrate energy balanced exercise

P. P. Gorski, D. C. Turner, J. Iraki, J. P. Morton, A. P. Sharples, J. L. Areta

This study examines DNA methylation changes in human skeletal muscle after low carbohydrate exercise under energy balance and deficit conditions, identifying hypomethylation in gene regions linked to metabolic pathways.

bioRxiv · Jan 19, 2023Physiology

The methylome and comparative transcriptome after high intensity sprint exercise in human skeletal muscle

M. F. Maasar, D. C. Turner, P. P. Gorski, R. A. Seaborne, J. A. Strauss, S. O. Shepherd, M. Cocks, N. J. Pillon, J. R. Zierath, A. T. Hulton, B. Drust, A. P. Sharples

This study examines the methylome and transcriptome changes in human skeletal muscle after high-intensity sprint exercise, finding that change of direction exercise causes greater epigenetic and gene expression changes than straight line sprinting.

bioRxiv · Sep 11, 2020 · PreprintPhysiology

Knockdown of the E3 Ubiquitin ligase UBR5 and its role in skeletal muscle anabolism

D. C. Turner, D. C. Hughes, L. M. Baehr, R. A. Seaborne, M. Viggars, J. C. Jarvis, P. P. Gorski, C. E. Stewart, D. J. Owens, S. C. Bodine, A. P. Sharples

This study shows that knocking down UBR5 leads to skeletal muscle atrophy by disrupting anabolic signaling pathways.

bioRxiv · Jun 5, 2020Cell Biology

DNA methylation across the genome in aged human skeletal muscle tissue and stem cells: The role of HOX genes and physical activity

D. C. Turner, P. P. Gorski, M. F. Maasar, R. A. Seaborne, P. Baumert, A. D. Brown, M. O. Kitchen, R. M. Erskine, I. Dos-Remedios, S. Voisin, N. Eynon, R. I. Sultanov, O. V. Borisov, A. K. Larin, E. A. Semenova, , A. P. Sharples

This study identifies age-related hypermethylation in HOX genes in aged human skeletal muscle and stem cells, with physical activity inversely affecting methylation in some genes.

bioRxiv · Dec 27, 2019Physiology

UBR5 is a Novel E3 Ubiquitin Ligase involved in Skeletal Muscle Hypertrophy and Recovery from Atrophy

R. A. Seaborne, D. C. Hughes, D. C. Turner, D. J. Owens, L. M. Baehr, P. Gorski, E. A. Semenova, O. V. Borisov, A. K. Larin, D. V. Popov, E. V. Generozov, H. Sutherland, I. I. Ahmetov, J. C. Jarvis, S. C. Bodine, A. P. Sharples

This paper identifies UBR5 as a novel E3 ubiquitin ligase inversely regulated to MuRF1/MAFbx, epigenetically modulated during skeletal muscle recovery from atrophy and hypertrophy, and genetically associated with muscle fiber size and strength traits.

bioRxiv · Apr 29, 2019Physiology

Comparative Transcriptome and Methylome Analysis in Human Skeletal Muscle Anabolism, Hypertrophy and Epigenetic Memory.

D. C. Turner, R. A. Seaborne, A. P. Sharples

This study identifies differentially methylated genes associated with human skeletal muscle anabolism, hypertrophy, and epigenetic memory by comparing transcriptome and methylome data from acute and chronic resistance exercise.

bioRxiv · Feb 15, 2019Physiology