J. Ratcliffe

Self-healing, biocompatible bioinks from self-assembled peptide and alginate hybrid hydrogels

This paper develops a hybrid bioink combining self-assembled peptides and alginate to create a stiff, printable, and self-healing material with improved biocompatibility for tissue engineering and biosensing.

Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity

This study investigates how SARS-CoV-2 peptides form amyloid assemblies with varying neurotoxicity and polymorphic structures, showing that aggregation conditions influence toxicity and cellular uptake.

Structural and biochemical characterization of LIG1 during mutagenic nick sealing of oxidatively damaged ends at the final step of DNA repair

This study characterizes LIG1's structural and biochemical interactions with oxidatively damaged DNA during the final steps of base excision repair.

Beclin1 is essential for intestinal homeostasis.

This study shows BECLIN1 is critical for intestinal homeostasis, as its deletion in adult mice causes fatal enteritis with compromised gut barrier integrity and morphological abnormalities.

Extensive collagen deposition by mesenchymal stem cells cultured in 3D self-assembled peptide scaffolds as revealed by nanoplasmonic colorimetric histology.

The paper investigates collagen deposition by mesenchymal stem cells in 3D peptide scaffolds and introduces a label-free method to image collagen.

Neurotoxic Amyloidogenic Peptides Identified in the Proteome of SARS-COV2: Potential Implications for Neurological Symptoms in COVID-19

The paper identifies amyloidogenic peptides in SARS-CoV-2 that are toxic to neuronal cells, suggesting they may contribute to neurological symptoms and long COVID.

Subtle, seasonal and potentially important: Are phytotoxic foliage leachates overlooked in plant invasion studies?

This study investigates seasonal variation in phytotoxic compounds from Rhododendron ponticum leaves and their impact on seed germination.

Fungus causing White-Nose Syndrome in bats accumulates genetic variability in North America and shows no sign of recombination

The paper analyzes the genetic variation of Pseudogymnoascus destructans in North America, finding population expansion and mutation accumulation but no recombination.