Author

M. D. Hulett

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:Arabidopsis· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. M. Abbott· 2 shared J. A. Wyllie· 2 shared M. A. Perugini· 2 shared S. Panjikar· 2 shared T. P. Soares da Costa· 2 shared A. Barrow· 1 shared A. Gendall· 1 shared A. R. Gendall· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersMicrobiology

B. M. Abbott

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

From bacteria to plants: a repurposing strategy in the pursuit for novel herbicides

E. Mackie, A. Barrow, M.-C. Giel, M. D. Hulett, A. Gendall, S. Panjikar, T. Soares da Costa

This study repurposes a failed antibiotic into a herbicide by targeting plant DHDPR, showing efficacy against weeds and no toxicity to human cells.

bioRxiv · Feb 20, 2022 · PreprintBiochemistry

The First Inhibitor of Meso-Diaminopimelate Biosynthesis with Antibacterial Activity Against Multi-Drug Resistant Bacteria

T. P. Soares da Costa, J. A. Wyllie, C. K. Ghardi, M. D. Hulett, B. M. Abbott, M. Sutton, M. A. Perugini

This paper identifies the first inhibitor of meso-DAP biosynthesis with antibacterial activity against multi-drug resistant A. baumannii, showing efficacy against carbapenem-resistant strains and biofilm disruption.

bioRxiv · Feb 10, 2022 · PreprintMicrobiology

Neurotoxic Amyloidogenic Peptides Identified in the Proteome of SARS-COV2: Potential Implications for Neurological Symptoms in COVID-19

S. Islam, M. Charnley, G. Bindra, J. Ratcliffe, J. Zhou, R. Mezzenga, M. D. Hulett, K. Han, J. T. Berryman, N. P. Reynolds

The paper identifies amyloidogenic peptides in SARS-CoV-2 that are toxic to neuronal cells, suggesting they may contribute to neurological symptoms and long COVID.

bioRxiv · Nov 24, 2021 · PreprintBiochemistry

Towards Novel Herbicide Modes of Action by Inhibiting Lysine Biosynthesis in Plants

T. P. Soares da Costa, C. J. Hall, S. Panjikar, J. A. Wyllie, R. M. Christoff, M. D. Hulett, S. Bayat, B. M. Abbott, A. R. Gendall, M. A. Perugini

This study identifies plant DHDPS inhibitors as a novel herbicide target, showing they inhibit lysine biosynthesis and demonstrate herbicidal activity against Arabidopsis thaliana.

bioRxiv · May 6, 2021Biochemistry