M. Charnley

Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity

This study investigates how SARS-CoV-2 peptides form amyloid assemblies with varying neurotoxicity and polymorphic structures, showing that aggregation conditions influence toxicity and cellular uptake.

Extensive collagen deposition by mesenchymal stem cells cultured in 3D self-assembled peptide scaffolds as revealed by nanoplasmonic colorimetric histology.

The paper investigates collagen deposition by mesenchymal stem cells in 3D peptide scaffolds and introduces a label-free method to image collagen.

E-cadherin in developing murine T cells controls spindle alignment and differentiation during β-selection

This study shows E-cadherin in murine T cells helps align the mitotic spindle and supports differentiation during β-selection by influencing immunological synapse formation.

Neurotoxic Amyloidogenic Peptides Identified in the Proteome of SARS-COV2: Potential Implications for Neurological Symptoms in COVID-19

The paper identifies amyloidogenic peptides in SARS-CoV-2 that are toxic to neuronal cells, suggesting they may contribute to neurological symptoms and long COVID.

Developing T cells form an immunological synapse for passage through the β-selection checkpoint

The paper shows developing T cells form an immunological synapse to pass the β-selection checkpoint, integrating signals from Notch, CXCR4, and MHC.

A new role for Notch in control of polarity and asymmetric cell division of developing T cells

This study shows Notch signaling directly controls asymmetric cell division in developing T cells by regulating Notch1 and fate determinants distribution.