Author

T. Russell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 2 Evolutionary Biology· 1 Immunology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

G. Barry· 2 shared G. Elliott· 2 shared J. Kite· 2 shared S. Abbott· 2 shared a. Alkhamees· 1 shared A. C. Carnegie· 1 shared A. Cori· 1 shared A. Enders· 1 shared

Activity by Year

2020-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

G. Barry

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

EpiFusion: Joint inference of the effective reproduction number by integrating phylodynamic and epidemiological modelling with particle filtering

C. Judge, T. Vaughan, T. Russell, S. Abbott, L. du Plessis, T. Stadler, O. Brady, S. Hill

EpiFusion improves estimation of outbreak dynamics by integrating phylodynamic and epidemiological data using particle filtering, enhancing accuracy and efficiency in large, poorly sampled epidemics.

bioRxiv · Dec 18, 2023Evolutionary Biology

Prediction of Bovine coronavirus immune epitopes using selection and phylogenetic analysis

T. Russell, J. M. Lozano, C. Challinor, G. Barry

This study predicts immune epitopes of BoCoV structural proteins and identifies recombination events and diversifying selection in Irish isolates.

bioRxiv · Sep 14, 2023 · PreprintMicrobiology

Bronchoconstriction damages airway epithelia by excess crowding-induced extrusion

D. C. Bagley, T. Russell, E. Ortiz-Zapater, K. Fox, P. F. Redd, M. Joseph, C. D. Rice, C. A. Reilly, M. Parsons, J. Rosenblatt

This study shows that bronchoconstriction causes epithelial cell extrusion, leading to airway damage, inflammation, and mucus secretion, and that inhibiting extrusion prevents these symptoms.

bioRxiv · Aug 4, 2023 · PreprintCell Biology

DOCK2-deficiency causes defects in anti-viral T cell responses and poor control of herpes simplex virus infection

K. L. Randall, I. E. A. Flesch, Y. Mei, L. A. Miosge, R. Aye, R. Aye, Z. Yu, H. Domaschenz, N. Hollett, T. Russell, T. Stefanovic, Y. C. Wong, C. C. Goodnow, E. Bertram, A. Enders, D. Tscharke

This study shows that DOCK2-deficient mice have impaired anti-viral CD8+ T cell responses and poor control of HSV-1 infection due to defects in clonal expansion and effector function.

bioRxiv · Aug 2, 2023 · PreprintImmunology

Improving modelling for epidemic responses: reflections from members of the UK infectious disease modelling community on their experiences during the COVID-19 pandemic

K. Sherratt, A. C. Carnegie, A. Kucharski, A. Cori, C. A. Pearson, C. I. Jarvis, C. Overton, D. Weston, E. M. Hill, E. Knock, E. Fearon, E. Nightingale, J. Hellewell, W. J. Edmunds, J. V. Arenas, , S. Abbott

The paper reflects on the experiences of UK infectious disease modellers during the COVID-19 pandemic, identifying challenges and proposing recommendations for future epidemic responses.

bioRxiv · Jun 12, 2023Scientific Communication & Education

Inhibition of potassium ion channels reduces Semliki Forest virus genome replication

T. Russell, C. O'Brien, D. Gangotia, S. Fulford, R. Kenny, a. Alkhamees, S. Premchand-Branker, R. Fragkoudis, D. Scholz, G. Barry

This study shows that K+ channel inhibitors reduce SFV replication and cytotoxicity in vitro by disrupting an early post-entry step, suggesting potential for antiviral repurposing.

bioRxiv · May 24, 2023 · PreprintMicrobiology

Cell-to-cell transmission of HSV1 in human keratinocytes in the absence of the major entry receptor, nectin1

J. Kite, T. Russell, J. Jones, G. Elliott

This study shows HSV1 can spread between human keratinocytes via direct cell-to-cell transmission even when the primary receptor nectin1 is absent.

bioRxiv · May 13, 2021Microbiology

Novel role for ESCRT-III component CHMP4C in the integrity of the endocytic network utilized for herpes simplex virus envelopment

T. Russell, J. Samolej, M. Hollinshead, G. L. Smith, J. Kite, G. Elliott

The paper identifies CHMP4C as a critical fission factor required for HSV1 envelopment by maintaining the integrity of the recycling endocytic network.

bioRxiv · Aug 19, 2020Cell Biology