Author

J. S. Chappie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 2 Cell Biology· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Assay:cryo-EM· 2 Organism:E. coli· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2

Frequent Co-Authors

M. C. Adams· 5 shared C. J. Hosford· 4 shared C. J. Schiltz· 3 shared C. Court· 2 shared D. L. Court· 2 shared M. L. Heck· 2 shared A. E. Leschziner· 1 shared C. J. Schlitz· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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5 shared papersMicrobiology

M. C. Adams

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The crystal structure of bacteriophage lambda RexA provides novel insights into the DNA binding properties of Rex-like phage exclusion proteins

M. C. Adams, C. J. Schiltz, J. Sun, C. J. Hosford, V. M. Johnson, H. Pan, P. P. Borbat, J. H. Freed, L. C. Thomason, C. Court, D. L. Court, J. S. Chappie

This paper presents the crystal structure of bacteriophage lambda RexA, revealing its DNA binding properties and evolutionary insights into phage exclusion mechanisms.

bioRxiv · Aug 31, 2023Microbiology

Polerovirus N-terminal readthrough domain structures reveal novel molecular strategies for mitigating virus transmission by aphids

C. J. Schiltz, J. R. Wilson, C. J. Hosford, M. C. Adams, S. E. Preising, S. L. DeBlasio, H. J. Macleod, J. Van Eck, M. L. Heck, J. S. Chappie

The paper reports crystal structures of polerovirus NRTDs, showing their dimeric structure and function in inhibiting aphid transmission.

bioRxiv · Apr 10, 2022Plant Biology

Crystal structure of the potato leafroll virus coat protein and implications for viral assembly

M. C. Adams, C. J. Schiltz, M. L. Heck, J. S. Chappie

The paper presents the crystal structure of a truncated coat protein from potato leafroll virus, revealing insights into viral assembly and the role of the N-terminus in capsid curvature.

bioRxiv · Aug 3, 2021Biochemistry

Bacteriophage Lambda RexA and RexB Functions Assist the Transition from Lysogeny to Lytic Growth

L. Thomason, D. L. Court, C. J. Schlitz, C. Court, C. J. Hosford, M. C. Adams, J. S. Chappie

The paper shows RexA and RexB proteins assist the transition from lysogenic to lytic growth in bacteriophage lambda by modulating CI and Cro repressors.

bioRxiv · Apr 19, 2021Microbiology

Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes

Y. Niu, H. Suzuki, C. J. Hosford, T. Walz, J. S. Chappie

This study reports cryo-EM structures of McrBC complexes from different bacteria, revealing structural asymmetry that governs GTPase activity and nuclease function.

bioRxiv · Jan 30, 2020Biochemistry

Cyclin N-Terminal Domain-Containing 1 (CNTD1) coordinates meiotic crossover formation with cell cycle progression in a cyclin-independent manner

S. Gray, E. Santiago, J. S. Chappie, P. E. Cohen

This study shows CNTD1 coordinates meiotic crossover formation with cell cycle progression in a cyclin-independent manner by interacting with Replication Factor C and the Skp1-Cullin1-F-Box complex.

bioRxiv · Aug 29, 2019Cell Biology

A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex

E. A. Partlow, R. W. Baker, G. M. Beacham, J. S. Chappie, A. E. Leschziner, G. Hollopeter

The paper reports cryo-EM structures of NECAP bound to phosphorylated AP2 and shows how phosphorylation marks AP2 for inactivation by NECAP.

bioRxiv · Jul 13, 2019Cell Biology

Endopeptidase regulation as a novel function of the Zur-dependent zinc starvation response

S. G. Murphy, L. Alvarez, M. C. Adams, S. Liu, J. S. Chappie, F. Cava, T. Dörr

This paper identifies ShyB, a zinc-dependent endopeptidase in Vibrio cholerae, as a novel component of the Zur-mediated zinc starvation response that sustains cell growth under low-zinc conditions.

bioRxiv · Sep 3, 2018Microbiology