Author

G. M. Beacham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:development & morphogenesis· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

G. Hollopeter· 4 shared E. A. Partlow· 2 shared A. E. Leschziner· 1 shared C. A. Alabi· 1 shared D. N. Thornlow· 1 shared D. T. Wei· 1 shared E. Beyrent· 1 shared J. C.-H. Kuo· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersCell Biology

G. Hollopeter

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Bio-orthogonal Glycan Imaging of Culture Cells and Whole Animal C. elegans with Expansion Microscopy

J. C.-H. Kuo, M. J. Colville, M. R. Sorkin, J. L. K. Kuo, L.-T. Huang, D. N. Thornlow, G. M. Beacham, G. Hollopeter, M. P. DeLisa, C. A. Alabi, M. J. Paszek

This paper develops multifunctional reagents for nanoscale imaging of glycans using expansion microscopy, validated in C. elegans and mammalian cells.

bioRxiv · Feb 1, 2024 · PreprintBioengineering

The C. elegans ASPP homolog APE-1 is a junctional protein phosphatase 1 modulator

G. M. Beacham, D. T. Wei, E. Beyrent, Y. Zhang, J. Zheng, M. M. K. Camacho, L. Florens, G. Hollopeter

The paper identifies APE-1 as a modulator of PP1 activity in C. elegans, showing it localizes PP1 to junctions and modulates phosphatase output through its ankyrin repeats.

bioRxiv · Feb 15, 2022 · PreprintCell Biology

A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex

E. A. Partlow, R. W. Baker, G. M. Beacham, J. S. Chappie, A. E. Leschziner, G. Hollopeter

The paper reports cryo-EM structures of NECAP bound to phosphorylated AP2 and shows how phosphorylation marks AP2 for inactivation by NECAP.

bioRxiv · Jul 13, 2019Cell Biology

NECAPs are negative regulators of the AP2 clathrin adaptor complex

G. M. Beacham, E. A. Partlow, J. J. Lange, G. Hollopeter

The paper identifies NECAPs as negative regulators of the AP2 clathrin adaptor complex by promoting its closed, inactive conformation and inactivating it late in endocytosis.

bioRxiv · Sep 22, 2017Cell Biology