Author

J. H. Freed

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

P. P. Borbat· 3 shared A. BriegeliD· 1 shared A. Flegel· 1 shared A. L. Lai· 1 shared A. Lai· 1 shared A. Muok· 1 shared A. R. Thiam· 1 shared B. E. Moeller· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersBiochemistry

P. P. Borbat

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Author profile →

5 papers

Recent·Most cited

The crystal structure of bacteriophage lambda RexA provides novel insights into the DNA binding properties of Rex-like phage exclusion proteins

M. C. Adams, C. J. Schiltz, J. Sun, C. J. Hosford, V. M. Johnson, H. Pan, P. P. Borbat, J. H. Freed, L. C. Thomason, C. Court, D. L. Court, J. S. Chappie

This paper presents the crystal structure of bacteriophage lambda RexA, revealing its DNA binding properties and evolutionary insights into phage exclusion mechanisms.

bioRxiv · Aug 31, 2023Microbiology

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

Y.-M. Choi, D. Ajjaji, K. D. Fleming, P. P. Borbat, M. L. Jenkins, B. E. Moeller, S. Fernando, S. R. Bhatia, J. H. Freed, J. E. Burke, A. R. Thiam, M. V. Airola

The paper investigates how lipid composition, specifically phosphatidic acid and diacylglycerol, affects PLIN3 recruitment to membranes and LDs, revealing structural changes in the PAT domain.

bioRxiv · Nov 17, 2022Biochemistry

Highly basic clusters in the HSV-1 nuclear egress complex drive membrane budding by inducing lipid ordering

M. K. Thorsen, A. Lai, M. W. Lee, D. P. Hoogerheide, G. C. L. Wong, J. H. Freed, E. E. Heldwein

This study identifies how basic regions in the HSV-1 nuclear egress complex induce lipid ordering and negative curvature to drive membrane budding, with phosphorylation inhibiting this process.

bioRxiv · May 18, 2021Microbiology

Engineered chemotaxis core signaling units indicate a constrained kinase-off state

A. Muok, T. Khiang Chua, M. Srivastava, W. Yang, Z. Maschmann, P. P. Borbat, J. Chong, S. Zhang, J. H. Freed, A. Briegel, B. R. Crane

The paper investigates how engineered chemoreceptor complexes stabilize a kinase-off state by sequestering kinase and substrate domains, using multiple biophysical techniques.

Science Signaling · Nov 10, 2020Peer-reviewedBiochemistry

Ca2+ ions promote fusion of Middle East Respiratory Syndrome coronavirus with host cells and increase infectivity

M. R. Straus, T. Tang, A. L. Lai, A. Flegel, M. Bidon, J. H. Freed, S. Daniel, G. R. Whittaker

This study shows that Ca2+ ions enhance MERS-CoV fusion and infectivity by interacting with specific residues in the spike protein's fusion peptide.

Journal of Virology · Jun 16, 2020Peer-reviewedMicrobiology