Y. Niu

Targeting PRMT3 Impairs Methylation and Oligomerization of HSP60 to Boost Anti-Tumor Immunity by Activating cGAS/STING Signaling

This study identifies PRMT3 as a driver of immunotherapy resistance in HCC, showing that targeting it enhances anti-tumor immunity via cGAS/STING activation.

hESCs-derived organoids achieve liver zonation by LSEC modulation

This study creates zonated liver organoids using hESCs-derived hepatocytes and LSECs, showing that GLP-1RA targets LSECs to alleviate NAFLD.

Distinct effects of CDK8 module subunits on cellular growth and proliferation in Drosophila

This study investigates the distinct roles of CDK8 module subunits in Drosophila, showing that Med12-Med13 disruption severely impacts ribosome biogenesis and growth, while CDK8-CycC affects cell-cycle progression.

Local nutrient addition drives plant biodiversity losses but not biotic homogenization in global grasslands

This study shows nutrient addition reduces plant diversity at local and larger scales equally, without causing biotic homogenization in global grasslands.

Phenotypic and transcriptional features of the Araliaceae species under distinct light environments

This study compares phenotypic and transcriptomic features of sun- and shade-grown Araliaceae species under different light conditions, revealing differences in photosynthesis efficiency and gene regulation.

An ovine model for investigation of the microenvironment of the male mammary gland

This study evaluates the male ovine mammary gland microenvironment, comparing intact and neutered males, and demonstrates its utility as a model for male breast biology.

Multidimensional responses of ecological stability to eutrophication in grasslands

This study quantifies how nutrient addition affects ecological stability facets in grasslands, finding reduced resistance in species richness and community composition but not biomass.

Epigenetic modifications mediate cultivar-specific root development and metabolic adaptation to nitrogen availability in wheat

Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation

This study shows that altering meal timing (restricted feeding) can restore intestinal clock function and reduce inflammation in IBD models.

Genetic and environmental circadian disruption induce metabolic impairment through changes in the gut microbiome

This study shows that circadian disruption from genetic and environmental factors causes metabolic issues by altering gut microbiome function and rhythmicity.

On the regulation of photosynthesis in pea leaves exposed to oscillating light.

The paper measures photosynthetic responses in pea leaves under oscillating light to understand regulatory networks in fluctuating irradiance conditions.

Plants cope with fluctuating light by frequency-dependent non-photochemical quenching and cyclic electron transport

This study investigates how plants regulate photoprotective mechanisms in fluctuating light, finding that different pathways respond to varying oscillation frequencies.

Phenotypic and transcriptomic responses of the sun- and shade-loving plants to sunlight and dim-light conditions

This study compares phenotypic and transcriptomic responses of sun- and shade-loving plants to sunlight and dim-light conditions, finding that shade-loving ginseng shows lower phenotypic plasticity but higher photosynthetic efficiency under dim light.

Identification of Six Thiolases and their Effects on Fatty Acid and Ergosterol Biosynthesis in Aspergillus oryzae

This study identifies six thiolases in Aspergillus oryzae and shows their roles in fatty acid and ergosterol biosynthesis, with some exhibiting dual functionality.

The intestinal circadian clock drives microbial rhythmicity to maintain gastrointestinal homeostasis

This study shows that the host's intestinal circadian clock regulates microbial rhythms, maintaining gut homeostasis through metabolite production and immune system modulation.

Analysis of the Mechanosensor Channel Functionality of TACAN

The paper investigates TACAN's functionality as a mechanosensitive ion channel and finds it does not exhibit mechanosensitive activity, instead showing structural features related to fatty acid elongase.

Chlorophyll fluorescence: How the quality of information about PAM instrument parameters may affect our research

The paper shows how PAM fluorometry measurements are affected by instrument parameter settings and calls for standardized documentation of protocols to improve data reliability and interpretation.

Dynamics of switching at stall reveals nonequilibrium mechanism in the allosteric regulation of the bacterial flagellar switch

The paper studies bacterial flagellar motor switching at stall and finds it behaves as an equilibrium process, revealing a non-equilibrium mechanism in its allosteric regulation.

The fungal root endophyte Serendipita vermifera displays inter-kingdom synergistic beneficial effects with the microbiota in Arabidopsis thaliana and barley

This study shows that the fungal endophyte Serendipita vermifera synergizes with bacterial microbiota to protect Arabidopsis and barley from pathogens, with benefits dependent on host and microbiota composition.

Resurrection of human endogenous retroviruses during aging reinforces senescence

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

Host preference and invasiveness of commensals in the Lotus and Arabidopsis root microbiota

The paper investigates host preference and invasiveness of commensal bacteria in the root microbiota of Lotus and Arabidopsis, showing host-specific adaptation and competitive advantages.

Single-PanIN-seq Unveils that ARID1A Deficiency Promotes Pancreatic Tumorigenesis by Attenuating KRAS Induced Senescence

The paper identifies ARID1A deficiency's role in promoting pancreatic tumorigenesis by reducing KRAS-induced senescence through upregulation of ALDH1A1 in mouse PanIN models.

Bone Marrow Stromal Cells in a Mouse Model of Implant Osseointegration

The paper identifies bone marrow stromal cell populations that contribute to implant osseointegration in a mouse model using lineage tracing and single-cell RNA-seq.

Mechanistic insights into ventricular arrhythmogenesis of hydroxychloroquine and azithromycin for the treatment of COVID-19

This study investigates the cardiac electrophysiological effects of hydroxychloroquine and azithromycin, showing they prolong QT intervals and increase arrhythmia risk when combined.

Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes

This study reports cryo-EM structures of McrBC complexes from different bacteria, revealing structural asymmetry that governs GTPase activity and nuclease function.

Inhibition mechanism of human sterol O-acyltransferase 1 by competitive inhibitor

This study determines the structure of human SOAT1 using cryo-EM and reveals how the inhibitor CI-976 blocks the active site.

Breeding of a high-yield strain for commercial cultivation by crossing Pholiota adiposa and P. limonella

The paper crosses Pholiota adiposa and P. limonella to develop a high-yield hybrid strain for commercial cultivation.

Characterization of aroma-active compounds in delicious apples juices by gas chromatography-mass spectrometry (GC-MS), gas chromatography-olfactometry (GC-O) and odor activity value (OAV)

This study identifies aroma-active compounds in three delicious apple juice cultivars using GC-MS, GC-O, and OAV, finding key contributors to the juice's aroma.

First evidence that intrinsic fetal heart rate variability exists and is affected by hypoxic pregnancy

This paper demonstrates that intrinsic fetal heart rate variability (iHRV) exists in late gestation and is significantly altered by chronic fetal hypoxia in sheep.

Extensive adaptive immune response of AAVs and Cas proteins in non-human primates

The paper investigates pre-existing adaptive immune responses to CRISPR Cas proteins and AAVs in non-human primates and finds such immunity is普遍存在 regardless of Cas proteins or AAVs.