J. T. Clark

PD-1 and CTLA-4 exert additive control of effector regulatory T cells

This study shows that PD-1 and CTLA-4 pathways additively regulate effector Treg cells by modulating their suppressive function and proliferation.

The enteric pathogen Cryptosporidium parvum exports proteins into the cytoplasm of the infected cell

This study identifies a Cryptosporidium secretion system that exports proteins into infected cells, triggering ER stress and contributing to pathogenesis.

IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii

The paper shows IL-33 enhances ILC-mediated resistance to Toxoplasma gondii by promoting IFN-γ production and reducing parasite replication.

PD-L1 - PD-1 interactions limit effector Treg cell populations at homeostasis and during infection

This study shows that PD-L1-PD-1 interactions regulate Treg cell populations at homeostasis and during infection, limiting their numbers to enhance pathogen-specific CD4+ T cell responses.

cDC1 Coordinate Innate and Adaptive Responses in the Omentum required for T cell Priming and Memory

This study shows that cDC1 in the omentum support T cell expansion and survival during Toxoplasma gondii infection, not T cell priming.