Author

A. H. Sharpe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Glatman Zaretsky· 1 shared A. I. Daud· 1 shared A. P. Hart· 1 shared A. S. Kumar· 1 shared B. Douglas· 1 shared C. A. Hunter· 1 shared C. Delaney· 1 shared C. Konradt· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperImmunology

A. Glatman Zaretsky

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma

M. Datta, S. Chatterjee, E. M. Perez, S. Gritsch, S. Roberge, M. Duquette, I. X. Chen, K. Naxerova, A. S. Kumar, M. Ghosh, K. E. Emblem, M. R. Ng, W. W. Ho, P. Kumar, S. Krishnan, , R. K. Jain

Losartan prevents ICB-induced cerebral edema and improves survival in glioblastoma mice, with a predictive immune signature identified.

bioRxiv · Jun 28, 2022 · PreprintCancer Biology

PD-L1 - PD-1 interactions limit effector Treg cell populations at homeostasis and during infection

J. A. Perry, J. T. Clark, J. Gullicksrud, J. DeLong, L. Shallberg, B. Douglas, A. P. Hart, C. Konradt, J. Park, A. Glatman Zaretsky, R. de Waal Malefyt, D. A. Christian, A. H. Sharpe, C. A. Hunter

This study shows that PD-L1-PD-1 interactions regulate Treg cell populations at homeostasis and during infection, limiting their numbers to enhance pathogen-specific CD4+ T cell responses.

bioRxiv · Dec 9, 2020 · PreprintImmunology

Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

K. E. Pauken, O. Shahid, K. A. Lagattuta, K. M. Mahuron, J. M. Luber, M. M. Lowe, L. Huang, C. Delaney, J. M. Long, M. E. Fung, K. Newcomer, K. K. Tsai, M. Chow, S. Guinn, J. R. Kuchroo, , M. Singer

The paper identifies circulating anti-tumor CD8 T cells using single-cell RNA sequencing and TCR sequencing, and develops marker panels for their detection in mice and melanoma patients.

bioRxiv · Sep 30, 2020Immunology