Intestinal cDC1s provide IL-12 dependent and independent functions required for CD4+ T cell mediated resistance to Cryptosporidium
I. S. Cohn, B. A. Wallbank, B. E. Haskins, K. M. O'Dea, R. D. Pardy, S. Shaw, M. I. Merolle, J. Gullicksrud, D. A. Christian, B. Striepen, C. A. Hunter
The paper investigates the role of intestinal cDC1s in CD4+ T cell-mediated resistance to Cryptosporidium, showing they support T cell expansion and effector function through IL-12-dependent and -independent mechanisms.
bioRxiv · Nov 11, 2023 · PreprintImmunology