Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors
D. M. Rasmussen, M. M. Semonis, J. T. Greene, J. M. Muretta, A. R. Thompson, S. T. Ramos, D. D. Thomas, W. C. K. Pomerantz, T. S. Freedman, N. M. Levinson
The paper explains how type II RAF inhibitors paradoxically activate BRAF by inducing asymmetric dimerization, using biophysical and structural methods.
bioRxiv · Apr 18, 2023Biophysics