M. I. Bliss

Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques

This study shows that ZIKV infection protects against SPONV in rhesus macaques, but not vice versa, suggesting one-way cross-protection between the viruses.

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

This study shows that African-lineage ZIKV infection in early first trimester causes high pregnancy loss in rhesus macaques, regardless of SIV status.

Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus

This study shows that high-dose African-lineage Zika virus infection in late first trimester pregnant rhesus macaques causes frequent fetal loss.

Early embryonic loss following intravaginal Zika virus challenge in rhesus macaques

This study infects rhesus macaques intravaginally with Zika virus and finds that two of three pregnancies resulted in early embryonic loss with viral RNA detected at the maternal-fetal interface.

Prior dengue immunity enhances Zika virus infection of the maternal-fetal interface in rhesus macaques

This study shows that prior dengue virus immunity enhances Zika virus infection at the maternal-fetal interface in rhesus macaques but does not affect plasma replication or fetal outcomes.

African-lineage Zika virus replication dynamics and maternal-fetal interface infection in pregnant rhesus macaques

This study infects pregnant rhesus macaques with African- and Asian-lineage Zika virus to compare their pathogenesis, finding similar replication kinetics but higher viral burden in maternal-fetal interface tissues with African-lineage isolates.