T. C. Friedrich

Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

Gain without pain: Adaptation and increased virulence of Zika virus in vertebrate host without fitness cost in mosquito vector

This study shows that ZIKV adapts to vertebrate hosts with increased virulence without reducing its ability to transmit via mosquitoes.

Vertical transmission of African-lineage Zika virus through the fetal membranes in a rhesus Macaque (Macaca mulatta) model

This study shows ZIKV can transmit vertically through fetal membranes, not the placenta, in rhesus macaques.

Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques

This study shows that ZIKV infection protects against SPONV in rhesus macaques, but not vice versa, suggesting one-way cross-protection between the viruses.

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

This study shows that African-lineage ZIKV infection in early first trimester causes high pregnancy loss in rhesus macaques, regardless of SIV status.

Transient T cell expansion, activation, and proliferation in therapeutically vaccinated SIV+ macaques treated with N-803

This study shows that therapeutic vaccination with a heterologous prime-boost regimen followed by N-803 treatment enhances CD8+ T cell responses in SIV-infected macaques.

Control of SIV infection in prophylactically vaccinated, ART-naïve macaques is required for the most efficacious CD8 T cell response during treatment with the IL-15 superagonist N-803

This study shows that N-803 treatment enhances CD8 T cell responses in SIV-infected macaques with low viral set-points, but not in those without prior immune control.

Infection of the maternal-fetal interface and vertical transmission following low-dose inoculation of pregnant rhesus macaques (Macaca mulatta) with an African-lineage Zika virus

This study shows African-lineage Zika virus can be vertically transmitted to rhesus macaque fetuses with a low dose, similar to Asian-lineage viruses.

Avian H7N9 influenza viruses are evolutionarily constrained by stochastic processes during replication and transmission in mammals

This study shows that H7N9 avian influenza viruses face strong evolutionary constraints during mammalian transmission, making human adaptation unlikely without rare, stochastic events.

Fetal loss in pregnant rhesus macaques infected with high-dose African-lineage Zika virus

This study shows that high-dose African-lineage Zika virus infection in late first trimester pregnant rhesus macaques causes frequent fetal loss.

Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks

This study tracks influenza A virus diversity in ferrets, showing compartmentalized replication and stochastic bottlenecks shaping genetic diversity within lung lobes.

Prior dengue immunity enhances Zika virus infection of the maternal-fetal interface in rhesus macaques

This study shows that prior dengue virus immunity enhances Zika virus infection at the maternal-fetal interface in rhesus macaques but does not affect plasma replication or fetal outcomes.

African-lineage Zika virus replication dynamics and maternal-fetal interface infection in pregnant rhesus macaques

This study infects pregnant rhesus macaques with African- and Asian-lineage Zika virus to compare their pathogenesis, finding similar replication kinetics but higher viral burden in maternal-fetal interface tissues with African-lineage isolates.

Rapid evolution of enhanced Zika virus virulence during direct vertebrate transmission chains

This study shows ZIKV adapts more rapidly to mice during direct transmission compared to mosquito or alternating host transmission, with a virulence-enhancing mutation emerging.

Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus

The paper assesses the feasibility of using a macaque model to study neurodevelopmental deficits from congenital Zika virus exposure and estimates required sample sizes for future studies.

Characteristic and quantifiable COVID-19-like abnormalities in CT- and PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques (Macaca fascicularis)

This study uses CT and PET/CT imaging to quantify SARS-CoV-2-induced lung abnormalities in crab-eating macaques, providing an objective endpoint for evaluating medical countermeasures.

Limited SARS-CoV-2 diversity within hosts and following passage in cell culture

This study analyzes SARS-CoV-2 within-host diversity using metagenomic sequencing and finds low genetic variation with limited evidence of positive selection in clinical and cell culture samples.

Quantifying within-host diversity of H5N1 influenza viruses in humans and poultry in Cambodia

The paper analyzes H5N1 influenza virus evolution in humans and ducks in Cambodia, finding human-adapting mutations but limited within-host evolution due to selection pressures.

Spondweni virus causes fetal harm in a mouse model of vertical transmission and is transmitted by Aedes aegypti mosquitoes

This study shows Spondweni virus causes fetal harm in mice and is transmitted by Aedes aegypti mosquitoes, similar to Zika virus.

Long-term protection of rhesus macaques from Zika virus reinfection

This study shows that rhesus macaques retain neutralizing antibodies against ZIKV for at least 27 months, protecting them from detectable plasma viremia upon rechallenge.

Extensive CD8β depletion does not prevent control of viral replication or protection from challenge in macaques chronically infected with a live attenuated simian immunodeficiency virus

This study shows that CD8β+ T cell depletion in SIV-infected macaques does not prevent viral control or protection from challenge, suggesting CD8β+ T cells are not essential for these outcomes.

Acute-phase CD4+ T cell responses targeting invariant viral regions are associated with control of live-attenuated simian immunodeficiency virus

This study shows that CD4+ T cell responses targeting invariant viral regions in MCMs without protective MHC alleles correlate with lower viral load during SIV infection.

Molecularly barcoded Zika virus libraries to probe in vivo evolutionary dynamics

This paper uses molecularly barcoded Zika virus to study in vivo infection dynamics in pregnant and non-pregnant macaques and mosquitoes, finding stable lineage proportions during acute infection but a rapid decline in complexity post-infection in pregnant animals.

Ocular and uteroplacental pathology in macaque congenital Zika virus infection

This study reports ocular and uteroplacental pathology in rhesus macaques infected with ZIKV during pregnancy, showing prolonged viral replication and severe fetal outcomes.

Highly Efficient Maternal-Fetal Zika Virus Transmission in Pregnant Rhesus Macaques

This study infects pregnant rhesus macaques with ZIKV and observes prolonged maternal viremia and fetal tissue infection, indicating efficient vertical transmission.

Oropharyngeal mucosal transmission of Zika virus in rhesus macaques

This study assesses the risk of Zika virus transmission through mucosal contact in rhesus macaques, finding that oral secretions from infected individuals pose a low transmission risk.