Author

R. A. Langlois

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2 Bioengineering· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Organism:mouse· 4 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. M. Thiede· 3 shared T. D. Bold· 3 shared V. D. Menachery· 3 shared W. E. Matchett· 3 shared J. Daniel· 2 shared J. K. Fiege· 2 shared M. K. Jenkins· 2 shared A. Barkhymer· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

J. M. Thiede

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

High-throughput investigation of genetic design constraints in domesticated Influenza A Virus for transient gene delivery

A. Sychla, C. Stach, S. Roach, A. Hayward, R. A. Langlois, M. Smanski

The paper investigates genetic design constraints in domesticated Influenza A Virus for transient gene delivery, identifying permissible mutations and RNA level motif depletion.

bioRxiv · Feb 14, 2024 · PreprintBioengineering

Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques

A. S. Jaeger, C. M. Crooks, A. M. Weiler, M. I. Bliss, S. L. Rybarczyk, A. Richardon, M. Einwalter, E. Peterson, S. Capuano, A. Barkhymer, J. T. Becker, J. T. Greene, T. S. Freedman, R. A. Langlois, T. C. Friedrich, M. T. Aliota

This study shows that ZIKV infection protects against SPONV in rhesus macaques, but not vice versa, suggesting one-way cross-protection between the viruses.

bioRxiv · Dec 16, 2022Microbiology

Influenza infection recruits distinct waves of regulatory T cells to the lung that limit lung resident IgA+ B cells

L. E. Sjaastad, D. L. Owen, S. Joo, T. P. Knutson, C. H. O'Connor, B. McClusky, R. S. LaRue, R. A. Langlois, M. A. Farrar

This study identifies two distinct regulatory T cell subsets in the lung during influenza infection and shows their role in modulating IgA+ B cells, with similar patterns observed in COVID-19 patients.

bioRxiv · Sep 19, 2022 · PreprintImmunology

Influenza virus replication in cardiomyocytes drives heart dysfunction and fibrosis

A. D. Kenney, S. L. Aron, C. Gilbert, N. Kumar, P. Chen, A. Eddy, L. Zhang, A. Zani, N. Vargas-Maldonado, S. Speaks, J. Kawahara, P. J. Denz, L. Dorn, F. Accornero, J. Ma, , J. S. Yount

This study shows that influenza virus directly infects cardiomyocytes, causing heart dysfunction and fibrosis, challenging the prevailing model of indirect cardiotoxicity.

bioRxiv · Oct 27, 2021Immunology

Nucleocapsid vaccine elicits spike-independent SARS-CoV-2 protective immunity

W. E. Matchett, V. Joag, J. M. Stolley, F. K. Shephard, C. F. Quarnstrom, C. K. Mickelson, S. Wijeyesinghe, A. G. Soerens, S. Becker, J. M. Thiede, E. Weyu, S. O'Flanagan, J. Walter, M. N. Vu, V. D. Menachery, , D. Masopust

This study shows that a nucleocapsid protein vaccine provides protective immunity against SARS-CoV-2, independent of spike protein targeting, in animal models.

bioRxiv · Apr 26, 2021Immunology

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium

J. K. Fiege, J. M. Thiede, H. Nanda, W. E. Matchett, P. J. Moore, N. R. Montanari, B. K. Thielen, J. Daniel, E. Stanley, R. C. Hunter, V. D. Menachery, S. S. Shen, T. D. Bold, R. A. Langlois

This study investigates SARS-CoV-2 tropism, antiviral responses, and therapy effectiveness in human airway epithelium using single-cell RNA-sequencing and flow cytometry.

bioRxiv · Oct 19, 2020Microbiology

SARS-CoV-2 neutralization and serology testing of COVID-19 convalescent plasma from donors with non-severe disease

T. J. Gniadek, J. M. Thiede, W. E. Matchett, A. R. Gress, K. A. Pape, M. K. Jenkins, V. D. Menachery, R. A. Langlois, T. D. Bold

The paper assesses SARS-CoV-2 neutralization and serology in convalescent plasma from non-severe COVID-19 donors, finding correlations between binding activity and neutralization.

bioRxiv · Aug 7, 2020Immunology

Analytical Validation of a COVID-19 qRT-PCR Detection Assay Using a 384-well Format and Three Extraction Methods

A. C. Nelson, B. Auch, M. Schomaker, D. M. Gohl, P. Grady, D. Johnson, R. Kincaid, K. E. Karnuth, J. Daniel, J. K. Fiege, E. J. Fay, T. Bold, R. A. Langlois, K. B. Beckman, S. Yohe

This study validates a qRT-PCR assay for SARS-CoV-2 detection using a 384-well format and three extraction methods, showing robust accuracy and sensitivity with commercial reagents.

bioRxiv · Apr 2, 2020 · PreprintPathology