S. Capuano

Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques

This study shows that ZIKV infection protects against SPONV in rhesus macaques, but not vice versa, suggesting one-way cross-protection between the viruses.

Discovery of a novel simian pegivirus in common marmosets (Callithrix jacchus) with lymphocytic enterocolitis

The paper discovers a novel simian pegivirus, SOBV, in common marmosets with lymphocytic enterocolitis, finds it prevalent in 34% of healthy marmosets, and notes its presence in clinically-normal marmosets at another center.

Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus

The paper assesses the feasibility of using a macaque model to study neurodevelopmental deficits from congenital Zika virus exposure and estimates required sample sizes for future studies.

Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques.

This study investigates whether prior dengue or Zika virus infection affects the severity of subsequent heterologous secondary infections in macaques, finding no significant impact on clinical outcomes.

Molecularly barcoded Zika virus libraries to probe in vivo evolutionary dynamics

This paper uses molecularly barcoded Zika virus to study in vivo infection dynamics in pregnant and non-pregnant macaques and mosquitoes, finding stable lineage proportions during acute infection but a rapid decline in complexity post-infection in pregnant animals.

Ocular and uteroplacental pathology in macaque congenital Zika virus infection

This study reports ocular and uteroplacental pathology in rhesus macaques infected with ZIKV during pregnancy, showing prolonged viral replication and severe fetal outcomes.

Infection via mosquito bite alters Zika virus replication kinetics in rhesus macaques

This study compares ZIKV replication kinetics and tissue distribution in rhesus macaques infected via mosquito bite versus subcutaneous inoculation, finding delayed viral peak and restricted tissue distribution in mosquito-infected animals.

Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection

Highly Efficient Maternal-Fetal Zika Virus Transmission in Pregnant Rhesus Macaques

This study infects pregnant rhesus macaques with ZIKV and observes prolonged maternal viremia and fetal tissue infection, indicating efficient vertical transmission.

Oropharyngeal mucosal transmission of Zika virus in rhesus macaques

This study assesses the risk of Zika virus transmission through mucosal contact in rhesus macaques, finding that oral secretions from infected individuals pose a low transmission risk.