Author

J. W. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

B. D. Stein· 1 shared B. J. Wick· 1 shared B. Ngo· 1 shared B. R. Webber· 1 shared B. S. Moriarity· 1 shared D. Wu· 1 shared E. E. Gardner· 1 shared E. J. Pomeroy· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

B. D. Stein

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Author profile →

2 papers

Recent·Most cited

Non-conserved metabolic regulation by LKB1 distinguishes human and mouse lung adenocarcinoma

B. D. Stein, J. R. Ferrarone, E. E. Gardner, J. W. Chang, D. Wu, Q. Chen, P. E. Hollstein, M. Yuan, R. J. Liang, J. S. Coukos, M. Sindelar, B. Ngo, S. S. Gross, R. J. Shaw, J. M. Asara, , L. C. Cantley

This study identifies a metabolic divergence between human and mouse lung adenocarcinomas due to LKB1-dependent regulation of TPI1 phosphorylation, highlighting limitations of mouse models for studying human cancer.

bioRxiv · Oct 1, 2021 · PreprintCancer Biology

Non-Viral Engineering of CAR-NK and CAR-T cells using the Tc Buster Transposon System™

E. J. Pomeroy, W. S. Lahr, J. W. Chang, J. B. Krueger, B. J. Wick, N. J. Slipek, J. G. Skeate, B. R. Webber, B. S. Moriarity

This paper demonstrates a non-viral method using the Tc Buster transposon system to deliver CAR constructs to primary human NK and T cells, achieving efficient gene expression and functional activity.

bioRxiv · Aug 2, 2021 · PreprintBioengineering