Author

S. R. van Hooff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

J. J. Molenaar· 3 shared M. M. van Noesel· 3 shared B. Koopmans· 2 shared F. C. P. Holstege· 2 shared J. Anderson· 2 shared J. Koster· 2 shared K. Straathof· 2 shared L. Schild· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

J. J. Molenaar

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Author profile →

4 papers

Recent·Most cited

Two opposing gene expression patterns within ATRX aberrant neuroblastoma

M. R. van Gerven, L. Schild, J. van Arkel, B. Koopmans, L. A. Broeils, L. A. M. Meijs, R. van Oosterhout, M. M. van Noesel, J. Koster, S. R. van Hooff, J. J. Molenaar, M. van den Boogaard

The paper identifies two opposing gene expression patterns in ATRX-aberrant neuroblastoma models, suggesting distinct molecular mechanisms and treatment implications.

bioRxiv · Oct 25, 2022 · PreprintCancer Biology

Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

J. Wienke, L. L. Visser, W. M. Kholosy, K. M. Keller, M. Barisa, S. Munnings-Tomes, E. Carlton, E. Poon, A. Rodriguez, R. Bernardi, F. Van den Ham, S. R. Van Hooff, Y. A. H. Matser, M. Tas, K. P. S. Langenberg, , J. J Molenaar

The paper uses single-cell RNA sequencing to analyze neuroblastoma and identifies the NECTIN2-TIGIT axis as a potential target for immunotherapy.

bioRxiv · Jul 15, 2022Cancer Biology

Loss of p16INK4a in neuroblastoma cells induces shift to an immature state with mesenchymal characteristics and increases sensitivity to EGFR inhibitors

N. A. Schubert, S. R. van Hooff, L. Schild, K. Ober, M. Hortensius, K. van den Handel, A. H. W. Essing, B. Koopmans, M. Boeije, N. Proost, M. van de Ven, S. Jansky, S. A. Stainczyk, U. H. Toprak, F. Westermann, , M. L. van den Boogaard

bioRxiv · Oct 27, 2021 · PreprintCancer Biology

Tumor to normal single cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

G. Kildisiute, W. M. Kholosy, M. D. Young, K. Roberts, R. Elmentaite, S. R. van Hooff, E. Khabirova, A. Piapi, C. Thevanesan, E. Bugallo Blanco, C. Burke, L. Mamanova, P. Lijnzaad, T. Margaritis, F. C. P. Holstege, , S. Behjati

The paper compares tumor and normal single-cell mRNA data to show neuroblastoma cells resemble fetal sympathoblasts across diverse samples.

bioRxiv · Jun 22, 2020Cancer Biology