Author

J. Worley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1

Frequent Co-Authors

A. Califano· 2 shared A. C. Doxey· 1 shared A. C. Iuga· 1 shared A. Curiel Garcia· 1 shared A. Griffin· 1 shared A. L. E. Wang· 1 shared A. Z. Obradovic· 1 shared B. J.-M. Tremblay· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

A. Califano

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single-Cell RNAseq Analysis Reveals Robust Anti-PD-1-Mediated Increase of Immune Infiltrate in Metastatic Castration-Sensitive Prostate Cancer

J. E. Hawley, A. Z. Obradovic, M. C. Dallos, E. A. Lim, K. Runcie, C. R. Ager, J. M. McKiernan, C. B. Anderson, G. J. Decastro, J. L. Weintraub, R. K. Virk, I. Lowy, J. Hu, M. G. Chaimowitz, X. V. Guo, , C. G. Drake

The paper analyzes single-cell RNAseq data from metastatic castration-sensitive prostate cancer patients treated with anti-PD-1 immunotherapy, showing increased immune infiltrate and identifying therapy-resistant tumor subpopulations and druggable targets.

bioRxiv · May 6, 2022 · PreprintCancer Biology

Developmental and MAPK-responsive transcription factors drive distinct malignant subtypes and genetic dependencies in pancreatic cancer

P. Laise, M. Turunen, A. Curiel Garcia, L. Tomassoni, C. Maurer, E. Elyada, B. Schmierer, J. Worley, J. Kesner, X. Tan, E. Calvo Fernandez, K. Wong, U. Wasko, S. Tagore, A. L. E. Wang, , A. Califano

The paper identifies three developmental lineages in pancreatic cancer driven by master regulators and shows their association with MAPK activity and therapeutic vulnerabilities.

bioRxiv · Oct 27, 2020 · PreprintCancer Biology

Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B

M. J. Mansfield, B. J.-M. Tremblay, J. Zeng, X. Wei, H. Hodgins, J. Worley, L. Bry, M. Dong, A. C. Doxey

This study analyzes 8,839 C. difficile genomes to reveal recombination-driven evolution of toxins A and B, develops a subtyping method, and creates a database for therapeutic and research use.

bioRxiv · Jul 9, 2020Microbiology