L. Bry

Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice

This study shows that PAHSAs improve insulin sensitivity in diet-induced obese mice via the gut microbiota, with sex-specific effects observed.

HRMAS 13C NMR and genome-scale metabolic modeling identify threonine as a preferred dual redox substrate for Clostridioides difficile

The TcdE holin drives toxin secretion and virulence in Clostridioides difficile.

This study shows that TcdE holin is essential for toxin secretion and virulence in C. difficile, as tcdE mutants exhibit reduced toxin release and less virulence in mice.

Central in vivo mechanisms by which C. difficile's proline reductase drives efficient metabolism, growth, and toxin production

This study shows that proline reductase in C. difficile is essential for metabolism, growth, and toxin production in vivo, as its absence delays colonization and disease progression in mice.

Elucidating dynamic anaerobe metabolism with HRMAS 13C NMR and genome-scale metabolic modeling.

This study uses HRMAS 13C NMR and genome-scale metabolic modeling to analyze dynamic anaerobic metabolism in Clostridioides difficile, revealing metabolic integration of glycolytic and amino acid fermentation pathways.

Clostridium scindens colonization of gnotobiotic mice promotes a chronic unresolving infection with Clostridioides difficile

This study shows that C. scindens colonization in gnotobiotic mice reduces acute C. difficile infection severity but does not prevent chronic infection development.

c-di-AMP signaling is required for bile salts resistance and long-term colonization by Clostridioides difficile

This study identifies c-di-AMP as a key signaling molecule in Clostridioides difficile that regulates osmolyte uptake and bile salt resistance, essential for gut colonization.

Real-time HRMAS 13C NMR of obligately anaerobic cells identifies new metabolic targets in the pathogen Clostridioides difficile

This study uses real-time HRMAS 13C NMR to analyze metabolism in C. difficile, identifying new metabolic integration points and informing a genome-scale model.

Phylogenomics of 8,839 Clostridioides difficile genomes reveals recombination-driven evolution and diversification of toxin A and B

This study analyzes 8,839 C. difficile genomes to reveal recombination-driven evolution of toxins A and B, develops a subtyping method, and creates a database for therapeutic and research use.

The mechanisms of in vivo commensal control of Clostridioides difficile virulence

This study identifies how commensal bacteria influence Clostridioides difficile virulence through metabolic and regulatory mechanisms in a mouse model.

Bacteriophages dynamically modulate the gut microbiota and metabolome

This study shows that bacteriophages affect gut bacteria and metabolites in mice, with cascading effects on the microbiome and implications for phage therapy.