GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control
Kelsey L. Hickey, Kimberley Dickson, J. Zachery Cogan, Joseph M. Replogle, Michael Schoof, Karole N. D’Orazio, Niladri K. Sinha, Jeffrey A. Hussmann, Marco Jost, Adam S. Frost, Rachel Green, Jonathan S. Weissman, Kamena K. Kostova
The paper identifies GIGYF2 and 4EHP as translation inhibitors that suppress re-initiation of defective mRNAs, aiding ribosome-associated quality control and preventing toxic protein accumulation.
Molecular Cell · Jul 28, 2020Peer-reviewedGenetics