Author

J.-C. Sirard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

J.-W. Veening· 3 shared X. Liu· 3 shared C. Costa· 2 shared J. Denereaz· 2 shared L. Matarazzo· 2 shared M. Baldry· 2 shared V. de Bakker· 2 shared A. Domenech· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersMicrobiology

J.-W. Veening

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Author profile →

4 papers

Recent·Most cited

A conserved antigen induces respiratory Th17-mediated serotype-independent protection against pneumococcal superinfection

X. Liu, L. Van Maele, L. Matarazzo, D. Soulard, V. Alves Duarte da Silva, V. de Bakker, J. Denereaz, F. P. Bock, M. Taschner, S. Gruber, V. Nizet, J.-C. Sirard, J.-W. Veening

The paper identifies a conserved antigen, LafB, that provides serotype-independent protection against pneumococcal superinfection via Th17 cells, independent of antibodies.

bioRxiv · Jul 7, 2023 · PreprintMicrobiology

Competence remodels the pneumococcal cell wall providing resistance to fratricide and surface exposing key virulence factors

V. Minhas, A. Domenech, D. Synefiaridou, D. Straume, M. Brendel, G. Cebrero, X. Liu, C. Costa, M. Baldry, J.-C. Sirard, C. Perez, N. Gisch, S. Hammerschmidt, L. S. Havarstein, J.-W. Veening

This study shows that competence in Streptococcus pneumoniae is crucial for virulence by increasing surface exposure of virulence factors and providing resistance to fratricide.

bioRxiv · Aug 3, 2022 · PreprintMicrobiology

Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

L. Dewachter, X. Liu, J. Denereaz, V. de Bakker, C. Costa, M. Baldry, J.-C. Sirard, J.-W. Veening

This paper identifies the mevalonate pathway as a target to resensitize amoxicillin-resistant Streptococcus pneumoniae using sCRilecs-seq.

bioRxiv · Sep 13, 2021Microbiology

Boosting Toll-like receptor 4 signaling enhances the therapeutic outcome of antibiotic therapy in pneumococcal pneumonia

F. Casilag, S. Franck, L. Matarazzo, M. Figeac, R. Michelet, C. Kloft, C. Carnoy, J.-C. Sirard

This study shows that combining TLR4 activation with antibiotics improves bacterial clearance and survival in pneumococcal pneumonia.

bioRxiv · Feb 18, 2020 · PreprintMicrobiology