Author

V. de Bakker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:CRISPR screen· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

J.-W. Veening· 5 shared X. Liu· 4 shared J. Denereaz· 2 shared J.-C. Sirard· 2 shared V. Nizet· 2 shared A. B. Janssen· 1 shared A. H. Froynes· 1 shared A. Prasad· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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5 shared papersMicrobiology

J.-W. Veening

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Author profile →

6 papers

Recent·Most cited

Genome-wide CRISPRi screens reveal the essentialome and determinants for susceptibility to dalbavancin in Staphylococcus aureus

X. Liu, V. de Bakker, M. V. Heggenhougen, M. T. Marli, A. H. Froynes, Z. Salehian, D. Porcellato, D. Morales Angeles, J.-W. Veening, M. Kjos

This study uses CRISPRi screens to identify genes affecting dalbavancin susceptibility in Staphylococcus aureus, revealing both known and novel factors.

bioRxiv · Aug 30, 2023Microbiology

Klebsiella pneumoniae OmpR facilitates lung infection through transcriptional regulation of key virulence factors

A. B. Janssen, V. de Bakker, R. Aprianto, V. Trebosc, C. Kemmer, M. Pieren, J.-W. Veening

This study shows that OmpR in Klebsiella pneumoniae regulates virulence and lung infection by controlling key virulence factors and eliciting a strong host transcriptional response.

bioRxiv · Jul 31, 2023 · PreprintMicrobiology

A conserved antigen induces respiratory Th17-mediated serotype-independent protection against pneumococcal superinfection

X. Liu, L. Van Maele, L. Matarazzo, D. Soulard, V. Alves Duarte da Silva, V. de Bakker, J. Denereaz, F. P. Bock, M. Taschner, S. Gruber, V. Nizet, J.-C. Sirard, J.-W. Veening

The paper identifies a conserved antigen, LafB, that provides serotype-independent protection against pneumococcal superinfection via Th17 cells, independent of antibodies.

bioRxiv · Jul 7, 2023 · PreprintMicrobiology

Deep divergence and genomic diversification of gut symbionts of neotropical stingless bees

G. Sarton-Loheac, C. G. Nunes da Silva, F. Mazel, G. Baud, V. de Bakker, S. Das, Y. El Chazli, K. M. Ellegaard, M. Garcia-Garcera, N. M. Glover, J. M. Liberti, L. Nacif Marcal, A. Prasad, V. Somerville, SAGE class 2019-2020 and 2020-2021, , P. Engel

The paper analyzes the gut microbiota of neotropical stingless bees, finding genomic divergence and evidence of host switches in their microbial evolution.

bioRxiv · Dec 8, 2022 · PreprintMicrobiology

Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

L. Dewachter, X. Liu, J. Denereaz, V. de Bakker, C. Costa, M. Baldry, J.-C. Sirard, J.-W. Veening

This paper identifies the mevalonate pathway as a target to resensitize amoxicillin-resistant Streptococcus pneumoniae using sCRilecs-seq.

bioRxiv · Sep 13, 2021Microbiology

Exploration of bacterial bottlenecks and Streptococcus pneumoniae pathogenesis by CRISPRi-seq

X. Liu, J. M. Kimmey, V. de Bakker, V. Nizet, J.-W. Veening

This study uses CRISPRi-seq to identify genetic factors important for Streptococcus pneumoniae pneumonia, revealing a critical bottleneck at 48 h post-infection and gene fitness differences between in vitro and in vivo conditions.

bioRxiv · Apr 22, 2020Microbiology