Author

A. W. Ensminger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:bacteria (other)· 4 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. Savchenko· 2 shared A.-C. Gingras· 2 shared H. O. Mount· 2 shared M. L. Urbanus· 2 shared P. J. Stogios· 2 shared R. R. Isberg· 2 shared S. R. Deecker· 2 shared A. C. Joyce· 1 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

A. Savchenko

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Author profile →

8 papers

Recent·Most cited

A comprehensive two-hybrid analysis to explore the L. pneumophila effector-effector interactome

H. O'Connor Mount, M. L. Urbanus, D. Sheykhkarimli, A. G. Cote, F. Laval, G. Coppin, N. Kishore, R. Li, K. Spirohn-Fitzgerald, M. O. Petersen, J. J. Knapp, D.-K. Kim, J.-C. Twizere, M. A. Calderwood, M. Vidal, , A. W. Ensminger

The paper uses a yeast two-hybrid screen to identify novel effector-effector interactions in L. pneumophila, doubling the known number of such interactions.

bioRxiv · Mar 29, 2024 · PreprintMicrobiology

Genetic evidence for a regulated cysteine protease catalytic triad in LegA7, a Legionella pneumophila protein that impinges on a stress response pathway

D. Hershkovitz, E. J. Chen, A. W. Ensminger, A. S. Dugan, K. T. Conway, A. C. Joyce, G. Segal, R. R. Isberg

The paper identifies LegA7 as a cysteine protease in L. pneumophila that regulates MAPK pathway activation through conserved residues and ankyrin repeats.

bioRxiv · Mar 17, 2024 · PreprintMicrobiology

A random mutagenesis screen enriched for missense mutations in bacterial effector proteins.

M. L. Urbanus, T. M. Zheng, A. N. Khusnutdinova, D. Banh, H. O. Mount, A. Gupta, P. J. Stogios, A. Savchenko, R. R. Isberg, A. F. Yakunin, A. W. Ensminger

The paper presents a yeast-based method to identify informative missense mutations in bacterial effector proteins and validates it using three effectors from Legionella pneumophila.

bioRxiv · Mar 14, 2024Microbiology

Functional diversification despite structural congruence in the HipBST toxin-antitoxin system of Legionella pneumophila

J. D. Lin, P. J. Stogios, K. T. Abe, A. Wang, J. MacPherson, T. Skarina, A.-C. Gingras, A. Savchenko, A. W. Ensminger

This study characterizes a conserved TA system in Legionella pneumophila, showing functional divergence from its E. coli counterpart despite structural similarity.

bioRxiv · Nov 26, 2022Microbiology

The L. pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4-NOT

H. O. Mount, F. Zangari, A.-C. Gingras, A. W. Ensminger

This study shows that the L. pneumophila effector PieF interacts with the CCR4-NOT complex to modulate mRNA stability and expression.

bioRxiv · Jun 6, 2022 · PreprintMicrobiology

Mobile element integration reveals a chromosome dimer resolution system in Legionellales.

B. Nicholson, S. R. Deecker, A. W. Ensminger

The paper identifies a novel dif/Xer system in Legionellales that resolves chromosome dimers and is linked to virulence in Legionella pneumophila and Coxiella burnetii.

bioRxiv · Sep 12, 2021Microbiology

Type I-F CRISPR-Cas distribution and array dynamics in Legionella pneumophila.

S. R. Deecker, A. W. Ensminger

This study investigates CRISPR-Cas type I-F systems in Legionella pneumophila, showing horizontal acquisition, co-occurrence with chromosomal loci, and primed spacer acquisition dynamics.

bioRxiv · Oct 7, 2019Microbiology

Priming In A Permissive Type I-C CRISPR-Cas System Reveals Distinct Dynamics Of Spacer Acquisition And Loss

C. Rao, D. Chin, A. W. Ensminger

This study examines primed adaptation in a type I-C CRISPR-Cas system of Legionella pneumophila, revealing dynamics of spacer acquisition, loss, and sequence constraints.

bioRxiv · May 12, 2017Microbiology